Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography

Erin E H Tran, James A. Simmons, Alberto Bartesaghi, Charles J. Shoemaker, Elizabeth Nelson, Judith M. White, Sriram Subramaniam

Research output: Contribution to journalArticlepeer-review

Abstract

The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.

Original languageEnglish (US)
Pages (from-to)10958-10962
Number of pages5
JournalJournal of Virology
Volume88
Issue number18
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Medicine(all)

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