Abstract
Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans.
Original language | English (US) |
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Pages (from-to) | 549-556 |
Number of pages | 8 |
Journal | Neurobiology of Aging |
Volume | 9 |
Issue number | C |
DOIs | |
State | Published - 1988 |
Externally published | Yes |
Keywords
- Aging
- Animal models
- High-affinity choline uptake
- Hippocampus
- Spatial learning
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology