Spatial learning deficits in old rats: A model for memory decline in the aged

Michela Gallagher, Mary Ann Pelleymounter

Research output: Contribution to journalReview article

Abstract

Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans.

Original languageEnglish (US)
Pages (from-to)549-556
Number of pages8
JournalNeurobiology of Aging
Volume9
Issue numberC
DOIs
StatePublished - 1988
Externally publishedYes

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Keywords

  • Aging
  • Animal models
  • High-affinity choline uptake
  • Hippocampus
  • Spatial learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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