Spatial effects in the detection of γ-aminobutyric acid: Improved sensitivity at high fields using inner volume saturation

Research output: Contribution to journalArticle

Abstract

The MEGA-PRESS-IVS method has been developed, which combines MEGA (a frequency-selective editing technique) editing with the point-resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing the deleterious effects of spatial variation in coupling evolution. The IVS method has been previously described for improved efficiency of lactate detection. The current study demonstrates that the combination of MEGA-PRESS with IVS results in increased sensitivity for edited single-voxel measurements of glutamate and gamma;-aminobutyric acid (GABA). A fourcompartment model of coupling evolution is investigated through simple product operators and full spin-system simulations and the predicted pattern of signal evolution is demonstrated through MEGA-PRESS-MRSI. MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24% is demonstrated in five healthy volunteers.

Original languageEnglish (US)
Pages (from-to)1276-1282
Number of pages7
JournalMagnetic Resonance in Medicine
Volume58
Issue number6
DOIs
StatePublished - Dec 2007

Fingerprint

Aminobutyrates
Spectrum Analysis
gamma-Aminobutyric Acid
Glutamic Acid
Lactic Acid
Healthy Volunteers

Keywords

  • 3 Tesla
  • Brain
  • GABA
  • Magnetic resonance spectroscopy
  • MEGA-PRESS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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title = "Spatial effects in the detection of γ-aminobutyric acid: Improved sensitivity at high fields using inner volume saturation",
abstract = "The MEGA-PRESS-IVS method has been developed, which combines MEGA (a frequency-selective editing technique) editing with the point-resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing the deleterious effects of spatial variation in coupling evolution. The IVS method has been previously described for improved efficiency of lactate detection. The current study demonstrates that the combination of MEGA-PRESS with IVS results in increased sensitivity for edited single-voxel measurements of glutamate and gamma;-aminobutyric acid (GABA). A fourcompartment model of coupling evolution is investigated through simple product operators and full spin-system simulations and the predicted pattern of signal evolution is demonstrated through MEGA-PRESS-MRSI. MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24{\%} is demonstrated in five healthy volunteers.",
keywords = "3 Tesla, Brain, GABA, Magnetic resonance spectroscopy, MEGA-PRESS",
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AB - The MEGA-PRESS-IVS method has been developed, which combines MEGA (a frequency-selective editing technique) editing with the point-resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing the deleterious effects of spatial variation in coupling evolution. The IVS method has been previously described for improved efficiency of lactate detection. The current study demonstrates that the combination of MEGA-PRESS with IVS results in increased sensitivity for edited single-voxel measurements of glutamate and gamma;-aminobutyric acid (GABA). A fourcompartment model of coupling evolution is investigated through simple product operators and full spin-system simulations and the predicted pattern of signal evolution is demonstrated through MEGA-PRESS-MRSI. MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24% is demonstrated in five healthy volunteers.

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