TY - JOUR
T1 - Spatial distribution of flow and oxygenation in the cerebral venous drainage system
AU - De Vis, Jill B.
AU - Lu, Hanzhang
AU - Ravi, Harshan
AU - Hendrikse, Jeroen
AU - Liu, Peiying
N1 - Funding Information:
Contract grant sponsor: National Institutes of Health (NIH); contract grant number: R01 AG042753; NIH R01 MH084021; NIH R01 AG047972; NIH R21 NS095342 (all to H.L.); NIH R21 NS085634 (to P.L.); Contract grant sponsor: Netherlands Organization for Scientific Research (NWO); contract grant number: 91712322 (to J.H.); Contract grant sponsor: European Research Council; contract grant number: 637024 (to J.H.)
PY - 2018/4
Y1 - 2018/4
N2 - Purpose: To investigate the venous oxygenation and flow in the brain, and determine how they might change under challenged states. Materials and Methods: Eight healthy human subjects (24–37 years) were studied. T 2 -relaxation under spin tagging (TRUST) magnetic resonance imaging (MRI) and phase-contrast MRI were performed to measure venous oxygenation and venous blood flow, respectively, in the superior sagittal sinus (SSS), the straight sinus (SS), and the internal jugular veins (IJVs). Venous oxygenation was assessed at room air (0.03%CO 2 , 21%O 2 ) and under hyperoxia (O%CO 2 , 95%O 2 , and 5%N 2 ) conditions. Venous blood flow was assessed at room air and under hypercapnia (5%CO 2 , 21%O 2 , and 74%N 2 ) conditions. Whole-brain blood flow was also measured at the four feeding arteries of the brain using phase-contrast MRI. The changes in venous oxygenation and blood flow from room air to hyperoxia or hypercapnia conditions were tested using paired t-tests. Results: Venous oxygenation in the SSS, the SS, and the IJVs was 61 ± 4%, 64 ± 4%, and 62 ± 4%, respectively, at room air, and increased to 70 ± 3% (P < 0.01 compared to room air), 71 ± 5% (P = 0.59), and 68 ± 5% (P < 0.05) under hyperoxic condition. The SSS, SS, and IJV drained 46 ± 9%, 16 ± 4%, and 79 ± 1% of whole-brain blood flow, respectively, and this flow distribution did not change under hypercapnic condition (P > 0.5). Conclusion: The results found in this study provide insight into the venous oxygenation and venous flow distribution and its heterogeneity among different venous structures. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:1091–1098.
AB - Purpose: To investigate the venous oxygenation and flow in the brain, and determine how they might change under challenged states. Materials and Methods: Eight healthy human subjects (24–37 years) were studied. T 2 -relaxation under spin tagging (TRUST) magnetic resonance imaging (MRI) and phase-contrast MRI were performed to measure venous oxygenation and venous blood flow, respectively, in the superior sagittal sinus (SSS), the straight sinus (SS), and the internal jugular veins (IJVs). Venous oxygenation was assessed at room air (0.03%CO 2 , 21%O 2 ) and under hyperoxia (O%CO 2 , 95%O 2 , and 5%N 2 ) conditions. Venous blood flow was assessed at room air and under hypercapnia (5%CO 2 , 21%O 2 , and 74%N 2 ) conditions. Whole-brain blood flow was also measured at the four feeding arteries of the brain using phase-contrast MRI. The changes in venous oxygenation and blood flow from room air to hyperoxia or hypercapnia conditions were tested using paired t-tests. Results: Venous oxygenation in the SSS, the SS, and the IJVs was 61 ± 4%, 64 ± 4%, and 62 ± 4%, respectively, at room air, and increased to 70 ± 3% (P < 0.01 compared to room air), 71 ± 5% (P = 0.59), and 68 ± 5% (P < 0.05) under hyperoxic condition. The SSS, SS, and IJV drained 46 ± 9%, 16 ± 4%, and 79 ± 1% of whole-brain blood flow, respectively, and this flow distribution did not change under hypercapnic condition (P > 0.5). Conclusion: The results found in this study provide insight into the venous oxygenation and venous flow distribution and its heterogeneity among different venous structures. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:1091–1098.
KW - brain MRI
KW - cerebral blood flow
KW - cerebral hemodynamics
KW - venous flow distribution
KW - venous oxygenation
KW - venous oxygenation distribution
UR - http://www.scopus.com/inward/record.url?scp=85043575155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043575155&partnerID=8YFLogxK
U2 - 10.1002/jmri.25833
DO - 10.1002/jmri.25833
M3 - Article
C2 - 28791759
AN - SCOPUS:85043575155
VL - 47
SP - 1091
EP - 1098
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 4
ER -