Spatial distribution of effects of negative pions on cultured human cells

P. Todd; C. R. Shonk; G. West; M. M. Kligerman; J. Dicello

doi:10.1148/116.1.179

Spatial distribution of effects of negative pions on cultured human cells

P. Todd, C. R. Shonk, G. West, M. M. Kligerman, J. Dicello

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cultured human kidney T 1 cells were irradiated in flasks or on coverslips at different depths in a water phantom using the Los Alamos Meson Physics Facility Biomedical negative pion beam. Postirradiation colony formation and cell multiplication were assayed. Maximum cell inactivation occurred in the vicinity of maximum pion dose. Comparison of dose survival curves with those found following x irradiation indicated RBE = 1.4 ± 0.3 for colony formation and approximately 1.5 growth delay. Delivery of 400 pion rads in 4 fractions resulted in higher survival than did delivery of 400 rads in a single fraction.

Original language	English (US)
Pages (from-to)	179-180+186
Journal	Unknown Journal
Volume	116
Issue number	1
DOIs	https://doi.org/10.1148/116.1.179
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/116.1.179

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abstract = "Cultured human kidney T 1 cells were irradiated in flasks or on coverslips at different depths in a water phantom using the Los Alamos Meson Physics Facility Biomedical negative pion beam. Postirradiation colony formation and cell multiplication were assayed. Maximum cell inactivation occurred in the vicinity of maximum pion dose. Comparison of dose survival curves with those found following x irradiation indicated RBE = 1.4 ± 0.3 for colony formation and approximately 1.5 growth delay. Delivery of 400 pion rads in 4 fractions resulted in higher survival than did delivery of 400 rads in a single fraction.",

author = "P. Todd and Shonk, {C. R.} and G. West and Kligerman, {M. M.} and J. Dicello",

year = "1975",

doi = "10.1148/116.1.179",

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AU - Todd, P.

AU - Shonk, C. R.

AU - West, G.

AU - Kligerman, M. M.

AU - Dicello, J.

PY - 1975

Y1 - 1975

N2 - Cultured human kidney T 1 cells were irradiated in flasks or on coverslips at different depths in a water phantom using the Los Alamos Meson Physics Facility Biomedical negative pion beam. Postirradiation colony formation and cell multiplication were assayed. Maximum cell inactivation occurred in the vicinity of maximum pion dose. Comparison of dose survival curves with those found following x irradiation indicated RBE = 1.4 ± 0.3 for colony formation and approximately 1.5 growth delay. Delivery of 400 pion rads in 4 fractions resulted in higher survival than did delivery of 400 rads in a single fraction.

AB - Cultured human kidney T 1 cells were irradiated in flasks or on coverslips at different depths in a water phantom using the Los Alamos Meson Physics Facility Biomedical negative pion beam. Postirradiation colony formation and cell multiplication were assayed. Maximum cell inactivation occurred in the vicinity of maximum pion dose. Comparison of dose survival curves with those found following x irradiation indicated RBE = 1.4 ± 0.3 for colony formation and approximately 1.5 growth delay. Delivery of 400 pion rads in 4 fractions resulted in higher survival than did delivery of 400 rads in a single fraction.

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Spatial distribution of effects of negative pions on cultured human cells

Abstract

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