Spatial distribution of effects of negative pions on cultured human cells

P. Todd, C. R. Shonk, G. West, M. M. Kligerman, J. Dicello

Research output: Contribution to journalArticlepeer-review

Abstract

Cultured human kidney T 1 cells were irradiated in flasks or on coverslips at different depths in a water phantom using the Los Alamos Meson Physics Facility Biomedical negative pion beam. Postirradiation colony formation and cell multiplication were assayed. Maximum cell inactivation occurred in the vicinity of maximum pion dose. Comparison of dose survival curves with those found following x irradiation indicated RBE = 1.4 ± 0.3 for colony formation and approximately 1.5 growth delay. Delivery of 400 pion rads in 4 fractions resulted in higher survival than did delivery of 400 rads in a single fraction.

Original languageEnglish (US)
Pages (from-to)179-180+186
JournalUnknown Journal
Volume116
Issue number1
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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