Spastic paraparesis and HTLV‐I infection in peru

Richard T. Johnson, Diane E. Griffin, Alberto Arregui, Carlos Mora, Clarence J. Gibbs, Juan M. Cuba, Luis Trelles, Abraham Vaisberg

Research output: Contribution to journalArticle

Abstract

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.

Original languageEnglish (US)
Pages (from-to)S151-S155
JournalAnnals of neurology
Volume23
Issue number1 S
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Johnson, R. T., Griffin, D. E., Arregui, A., Mora, C., Gibbs, C. J., Cuba, J. M., Trelles, L., & Vaisberg, A. (1988). Spastic paraparesis and HTLV‐I infection in peru. Annals of neurology, 23(1 S), S151-S155. https://doi.org/10.1002/ana.410230734