Spanish validation of the HIV dementia scale in women

V. Wojna, Richard Skolasky, Justin Charles McArthur, E. Maldonado, R. Hechavarria, R. Mayo, O. Selnes, T. Ginebra, T. De La Torre, H. Garcia, E. Kraiselburd, L. M. Melendez-Guerrero, C. D. Zorrilla, A. Nath

Research output: Contribution to journalArticle

Abstract

HIV infection is increasing in minority groups, particularly in African American and Hispanic women. Although the incidence of HIV dementia has decreased since the advent of highly active antiretroviral treatment, prevalence of neurocognitive complications has increased as patients are now living longer. This study's purpose was to determine the psychometric properties of the Spanish-language HIV Dementia Scale (HDS) in a group of HIVinfected women. We recruited 96 women: 60 HIV-seropositive and 36 HIV-seronegative. Modification of the HDS into a Spanish-language version consisted of translating the instructions, substituting four words in Spanish (gato, media, azul, piña), increasing 1 second in the psychomotor speed because the Spanish alphabet has more letters than the English alphabet, and not offering clues for memory recall. Cognitive impairment (CI) was defined according to the modified American Academy of Neurology HIV-dementia criteria including an asymptomatic CI group. Statistical analysis consisted of analysis of variance to determine group differences and receiver operator characteristics (ROC) to determine the optimal cutoff point for the screening of CI. HDS-Spanish total score and subscores for psychomotor speed and memory recall showed significant differences between HIV-seronegative and women with HIV-dementia (p <0.001) and between HIV-seropositive women with normal cognition and those with HIV-dementia (p <0.001). The optimal cutoff point of 13 or less had performance characteristics of 87% sensitivity and 46% specificity for HIV-associated CI (50.0% positive predictive value, 85.0% negative predictive value). The HDS-Spanish translation offers a useful screening tool with value for the identification of Hispanic women at risk of developing HIV-associated symptomatic neurocognitive disturbances.

Original languageEnglish (US)
Pages (from-to)930-941
Number of pages12
JournalAIDS Patient Care and STDs
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2007

Fingerprint

AIDS Dementia Complex
HIV
Hispanic Americans
Pinta
Language
Minority Groups
Psychometrics
African Americans
Cognition
HIV Infections
Analysis of Variance
Sensitivity and Specificity
Cognitive Dysfunction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

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Spanish validation of the HIV dementia scale in women. / Wojna, V.; Skolasky, Richard; McArthur, Justin Charles; Maldonado, E.; Hechavarria, R.; Mayo, R.; Selnes, O.; Ginebra, T.; De La Torre, T.; Garcia, H.; Kraiselburd, E.; Melendez-Guerrero, L. M.; Zorrilla, C. D.; Nath, A.

In: AIDS Patient Care and STDs, Vol. 21, No. 12, 01.12.2007, p. 930-941.

Research output: Contribution to journalArticle

Wojna, V, Skolasky, R, McArthur, JC, Maldonado, E, Hechavarria, R, Mayo, R, Selnes, O, Ginebra, T, De La Torre, T, Garcia, H, Kraiselburd, E, Melendez-Guerrero, LM, Zorrilla, CD & Nath, A 2007, 'Spanish validation of the HIV dementia scale in women', AIDS Patient Care and STDs, vol. 21, no. 12, pp. 930-941. https://doi.org/10.1089/apc.2006.0180
Wojna, V. ; Skolasky, Richard ; McArthur, Justin Charles ; Maldonado, E. ; Hechavarria, R. ; Mayo, R. ; Selnes, O. ; Ginebra, T. ; De La Torre, T. ; Garcia, H. ; Kraiselburd, E. ; Melendez-Guerrero, L. M. ; Zorrilla, C. D. ; Nath, A. / Spanish validation of the HIV dementia scale in women. In: AIDS Patient Care and STDs. 2007 ; Vol. 21, No. 12. pp. 930-941.
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