SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner

P. Richard Grimm, Tarvinder K. Taneja, Jie Liu, Richard Coleman, Yang Yi Chen, Eric Delpire, James B. Wade, Paul A. Welling

Research output: Contribution to journalArticle

Abstract

Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC activation. Conclusion: SPAK and OSR1 function interdependently in the DCT to positively regulate NCC. Significance: This study provides insights into the mechanisms whereby SPAK/OSR1 regulates renal salt transport.

Original languageEnglish (US)
Pages (from-to)37673-37690
Number of pages18
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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