Sources of variance in the measurement of intrapulmonary killing of bacteria

David Ruppert, George J. Jakab, David L. Sylwester, Gareth M. Green

Research output: Contribution to journalArticle

Abstract

Sources of variability are described for a method used for the quantitative measurement of pulmonary resistance to inhaled bacteria in individual animals. Factors contributing significantly to variability include aerosol exposure chamber design, bacterial species used for aerosol challenge, location of animals in the chamber, and individual intrapulmonary bacterial killing rates. Laboratory error accounted for a small portion of the variance. The data demonstrate that with appropriate modifications in protocol, statistical design and analysis experiments can be performed with increased accuracy, thereby reducing the number of animals needed for each experiment.

Original languageEnglish (US)
Pages (from-to)544-558
Number of pages15
JournalThe Journal of laboratory and clinical medicine
Volume87
Issue number3
StatePublished - Mar 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Ruppert, D., Jakab, G. J., Sylwester, D. L., & Green, G. M. (1976). Sources of variance in the measurement of intrapulmonary killing of bacteria. The Journal of laboratory and clinical medicine, 87(3), 544-558.