Source-based morphometry: The use of independent component analysis to identify gray matter differences with application to schizophrenia

Lai Xu, Karyn M. Groth, Godfrey Pearlson, David Schretlen, Vince Daniel Calhoun

Research output: Contribution to journalArticle

Abstract

We present a multivariate alternative to the voxel-based morphometry (VBM) approach called source-based morphometry (SBM), to study gray matter differences between patients and healthy controls. The SBM approach begins with the same preprocessing procedures as VBM. Next, independent component analysis is used to identify naturally grouping, maximally independent sources. Finally, statistical analyses are used to determine the significant sources and their relationship to other variables. The identified ''source networks,'' groups of spatially distinct regions with common covariation among subjects, provide information about localization of gray matter changes and their variation among individuals. In this study, we first compared VBM and SBM via a simulation and then applied both methods to real data obtained from 120 chronic schizophrenia patients and 120 healthy controls.SBM identified five gray matter sources as significantly associated with schizophrenia. These included sources in the bilateral temporal lobes, thalamus, basal ganglia, parietal lobe, and frontotemporal regions. None of these showed an effect of sex. Two sources in the bilateral temporal and parietal lobes showed age-related reductions. The most significant source of schizophrenia-related gray matter changes identified by SBM occurred in the bilateral temporal lobe, while the most significant change found by VBM occurred in the thalamus. The SBM approach found changes not identified by VBM in basal ganglia, parietal, and occipital lobe. These findings show that SBM is a multivariate alternative to VBM, with wide applicability to studying changes in brain structure.

Original languageEnglish (US)
Pages (from-to)711-724
Number of pages14
JournalHuman Brain Mapping
Volume30
Issue number3
DOIs
StatePublished - Mar 2009

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Keywords

  • Independent component analysis
  • Schizophrenia
  • Source-based morphometry
  • Structural MRI
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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