Source-based morphometry: a decade of covarying structural brain patterns

Cota Navin Gupta, Jessica A. Turner, Vince D. Calhoun

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


In this paper, we review and discuss brain imaging studies which have used the source-based morphometry (SBM) approach over the past decade. SBM is a data-driven linear multivariate approach for decomposing structural brain imaging data into commonly covarying imaging components and subject-specific loading parameters. It is a well-established technique which has predominantly been used to study neuroanatomic differences between healthy controls and patients with neuropsychiatric diseases. We start by discussing the advantages of this technique over univariate analysis for imaging studies, followed by a discussion of results from recent studies which have successfully applied this methodology. We also present recent extensions of this framework including nonlinear SBM, biclustered independent component analysis (B-ICA) and conclude with the possible directions of work for future.

Original languageEnglish (US)
Pages (from-to)3031-3044
Number of pages14
JournalBrain Structure and Function
Issue number9
StatePublished - Dec 1 2019


  • Biclustered independent component analysis (B-ICA)
  • Independent component analysis (ICA)
  • Multivariate analysis
  • Nonlinear independent component analysis (NICE)
  • Source-based morphometry (SBM)
  • Univariate analysis
  • Voxel-based morphometry (VBM)

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology


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