TY - JOUR
T1 - Sonographic assessment of tumor response
T2 - From in vivo models to clinical applications
AU - Hwang, Misun
AU - Niermann, Kenneth J.
AU - Lyshchik, Andrej
AU - Fleischer, Arthur C.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - The advent of antiangiogenic drugs in cancer therapy necessitates an imaging modality that can longitudinally assess posttreatment changes in tumor vasculature. In this regard, microbubble contrast-enhanced ultrasonography (CEUS) offers several advantages over conventional imaging modalities. The small size of microbubbles (approximately 2-3 μm) permits their retention in the intravascular compartment and travel through the tortuous tumor vasculature. Mathematical models applied to signal intensity versus time depicting the kinetics of microbubble flow through the tumor are used to characterize tumor vascular density, blood flow velocity, and perfusion. In vivo studies using CEUS have demonstrated its comparability to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in distinguishing between diseased or malignant tissue and normal tissue. Moreover, CEUS has great potential for other novel clinical applications such as improved cancer diagnosis, enhanced medication delivery, and early antiangiogenic cancer treatment response evaluation. This review discusses the principles and potential clinical applications of CEUS in determining tumor response and its promising role in enhancing medication delivery in certain tumors.
AB - The advent of antiangiogenic drugs in cancer therapy necessitates an imaging modality that can longitudinally assess posttreatment changes in tumor vasculature. In this regard, microbubble contrast-enhanced ultrasonography (CEUS) offers several advantages over conventional imaging modalities. The small size of microbubbles (approximately 2-3 μm) permits their retention in the intravascular compartment and travel through the tortuous tumor vasculature. Mathematical models applied to signal intensity versus time depicting the kinetics of microbubble flow through the tumor are used to characterize tumor vascular density, blood flow velocity, and perfusion. In vivo studies using CEUS have demonstrated its comparability to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in distinguishing between diseased or malignant tissue and normal tissue. Moreover, CEUS has great potential for other novel clinical applications such as improved cancer diagnosis, enhanced medication delivery, and early antiangiogenic cancer treatment response evaluation. This review discusses the principles and potential clinical applications of CEUS in determining tumor response and its promising role in enhancing medication delivery in certain tumors.
KW - Angiogenesis
KW - Contrast
KW - Microbubble
KW - Tumor
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=74249112378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74249112378&partnerID=8YFLogxK
U2 - 10.1097/RUQ.0b013e3181bce364
DO - 10.1097/RUQ.0b013e3181bce364
M3 - Review article
C2 - 19956050
AN - SCOPUS:74249112378
VL - 25
SP - 175
EP - 183
JO - Ultrasound Quarterly
JF - Ultrasound Quarterly
SN - 0894-8771
IS - 4
ER -