Sonic Hedgehog Signaling and Hippocampal Neuroplasticity

Pamela J. Yao, Ronald S. Petralia, Mark P. Mattson

Research output: Contribution to journalReview article

Abstract

Sonic hedgehog (Shh) is a secreted protein that controls the patterning of neural progenitor cells, and their neuronal and glial progeny, during development. Emerging findings suggest that Shh also has important roles in the formation and plasticity of neuronal circuits in the hippocampus, a brain region of fundamental importance in learning and memory. Shh mediates activity-dependent and injury-induced hippocampal neurogenesis. Activation of Shh receptors in the dendrites of hippocampal neurons engages a trans-neuronal signaling pathway that accelerates axon outgrowth and enhances glutamate release from presynaptic terminals. Impaired Shh signaling may contribute to the pathogenesis of several developmental and adult-onset neurological disorders that affect the hippocampus, suggesting a potential for therapeutic interventions that target Shh pathways.

Original languageEnglish (US)
Pages (from-to)840-850
Number of pages11
JournalTrends in Neurosciences
Volume39
Issue number12
DOIs
StatePublished - Dec 1 2016

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Neuronal Plasticity
Hippocampus
Neurogenesis
Presynaptic Terminals
Dendrites
Nervous System Diseases
Neuroglia
Glutamic Acid
Stem Cells
Learning
Neurons
Wounds and Injuries
Brain
Proteins
Therapeutics
Neuronal Outgrowth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sonic Hedgehog Signaling and Hippocampal Neuroplasticity. / Yao, Pamela J.; Petralia, Ronald S.; Mattson, Mark P.

In: Trends in Neurosciences, Vol. 39, No. 12, 01.12.2016, p. 840-850.

Research output: Contribution to journalReview article

Yao, Pamela J. ; Petralia, Ronald S. ; Mattson, Mark P. / Sonic Hedgehog Signaling and Hippocampal Neuroplasticity. In: Trends in Neurosciences. 2016 ; Vol. 39, No. 12. pp. 840-850.
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