'Something so hard': A mixed-methods study of home sputum collection for tuberculosis contact investigation in Uganda

M. Armstrong-Hough, J. Ggita, P. Turimumahoro, A. J. Meyer, E. Ochom, David Wesley Dowdy, A. Cattamanchi, A. Katamba, J. L. Davis

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Home sputum collection could facilitate prompt evaluation and diagnosis of tuberculosis (TB) among contacts of patients with active TB. We analyzed barriers to home-based collection as part of an enhanced intervention for household TB contact investigation in Kampala, Uganda. DESIGN: We conducted a convergent mixed-methods study to describe the outcomes of home sputum collection in 91 contacts and examine their context through 19 nested contact interviews and two focus group discussions with lay health workers (LHWs). RESULTS: LHWs collected sputum from 35 (39%) contacts. Contacts reporting cough were more likely to provide sputum than those with other symptoms or risk factors (53% vs. 15%, RR 3.6, 95%CI 1.5-2.8, P, 0.001). Males were more likely than females to provide sputum (54% vs. 32%, RR 1.7, 95%CI 1.0-2.8, P ¼ 0.05). Contacts said support from the index patient and the convenience of the home visit facilitated collection. Missing containers and difficulty producing sputum spontaneously impeded collection. Women identified stigma as a barrier. LHWs emphasized difficulty in procuring sputum and discomfort pressing contacts to produce sputum. CONCLUSIONS: Home sputum collection by LHWs entails different challenges from sputum collection in clinical settings. More research is needed to develop interventions to mitigate stigma and increase success of home-based collection.

Original languageEnglish (US)
Pages (from-to)1152-1159
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2018

Keywords

  • Gender
  • Household contact investigation
  • Lay health workers
  • Sputum collection
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Armstrong-Hough, M., Ggita, J., Turimumahoro, P., Meyer, A. J., Ochom, E., Dowdy, D. W., Cattamanchi, A., Katamba, A., & Davis, J. L. (2018). 'Something so hard': A mixed-methods study of home sputum collection for tuberculosis contact investigation in Uganda. International Journal of Tuberculosis and Lung Disease, 22(10), 1152-1159. https://doi.org/10.5588/ijtld.18.0129