Some characteristics of the p-chlorophenylalanine-induced cataract

V. D. Rowe, S. Zigler, A. E. Andersen, J. B. Sidbury, G. Guroff

Research output: Contribution to journalArticle

Abstract

A description of the cataract produced in young rats by the injection of p-chlorophenylalanine and phenylalanine in terms of amino acid analysis and agar gel electrophoresis is presented. A decrease in all amino acids except aspartic acid, and a striking change in the electrophoretic pattern of the soluble protein in the cataractous lenses was noted. The glutathione content of cataractous lens was low as compared with the glutathione content of the contralateral, normal-appearing lens. Grossly visible cataracts appeared several months after the injections had ceased.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalExperimental eye research
Volume17
Issue number3
DOIs
StatePublished - Nov 11 1973

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Rowe, V. D., Zigler, S., Andersen, A. E., Sidbury, J. B., & Guroff, G. (1973). Some characteristics of the p-chlorophenylalanine-induced cataract. Experimental eye research, 17(3), 245-250. https://doi.org/10.1016/0014-4835(73)90175-9