Some characteristics of the p-chlorophenylalanine-induced cataract

V. D. Rowe, S. Zigler, A. E. Andersen, J. B. Sidbury, G. Guroff

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A description of the cataract produced in young rats by the injection of p-chlorophenylalanine and phenylalanine in terms of amino acid analysis and agar gel electrophoresis is presented. A decrease in all amino acids except aspartic acid, and a striking change in the electrophoretic pattern of the soluble protein in the cataractous lenses was noted. The glutathione content of cataractous lens was low as compared with the glutathione content of the contralateral, normal-appearing lens. Grossly visible cataracts appeared several months after the injections had ceased.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalExperimental eye research
Issue number3
StatePublished - Nov 11 1973

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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