Some characteristics of the p-chlorophenylalanine-induced cataract

V. D. Rowe; S. Zigler; A. E. Andersen; J. B. Sidbury; G. Guroff

doi:10.1016/0014-4835(73)90175-9

Some characteristics of the p-chlorophenylalanine-induced cataract

V. D. Rowe, S. Zigler, A. E. Andersen, J. B. Sidbury, G. Guroff

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A description of the cataract produced in young rats by the injection of p-chlorophenylalanine and phenylalanine in terms of amino acid analysis and agar gel electrophoresis is presented. A decrease in all amino acids except aspartic acid, and a striking change in the electrophoretic pattern of the soluble protein in the cataractous lenses was noted. The glutathione content of cataractous lens was low as compared with the glutathione content of the contralateral, normal-appearing lens. Grossly visible cataracts appeared several months after the injections had ceased.

Original language	English (US)
Pages (from-to)	245-250
Number of pages	6
Journal	Experimental eye research
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0014-4835(73)90175-9
State	Published - Nov 11 1973
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(73)90175-9

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AU - Zigler, S.

AU - Andersen, A. E.

AU - Sidbury, J. B.

AU - Guroff, G.

PY - 1973/11/11

Y1 - 1973/11/11

N2 - A description of the cataract produced in young rats by the injection of p-chlorophenylalanine and phenylalanine in terms of amino acid analysis and agar gel electrophoresis is presented. A decrease in all amino acids except aspartic acid, and a striking change in the electrophoretic pattern of the soluble protein in the cataractous lenses was noted. The glutathione content of cataractous lens was low as compared with the glutathione content of the contralateral, normal-appearing lens. Grossly visible cataracts appeared several months after the injections had ceased.

AB - A description of the cataract produced in young rats by the injection of p-chlorophenylalanine and phenylalanine in terms of amino acid analysis and agar gel electrophoresis is presented. A decrease in all amino acids except aspartic acid, and a striking change in the electrophoretic pattern of the soluble protein in the cataractous lenses was noted. The glutathione content of cataractous lens was low as compared with the glutathione content of the contralateral, normal-appearing lens. Grossly visible cataracts appeared several months after the injections had ceased.

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Some characteristics of the p-chlorophenylalanine-induced cataract

Abstract

ASJC Scopus subject areas

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