Somatostatin suppression of canine fasting bile secretion

J. B. Hanks, W. J. Kortz, D. K. Andersen, R. S. Jones

Research output: Contribution to journalArticle

Abstract

Somatostatin, a peptide present in hypothalamus, gastric mucosa, and pancreas, suppresses several gastrointestinal functions. We evaluated the effect of graded doses of intravenous somatostatin on taurocholate-stimulated bile flow in awake fasting dogs. Somatostatin doses of 1.5-200 ng.kg-1.min-1 significantly suppressed fasting biliary flow. Biliary lipid concentration showed progressive elevations approaching 200% with 200 ng.kg-1.min-1 somatostatin, while lipid outputs were not altered. The data suggest that somatostatin inhibited bile salt-independent canalicular or ductular secretion, because bile flow, chloride, and bicarbonate output, and the biliary clearance of erythritol were significantly reduced, while bile salt output remained unchanged. In addition, suppression of basal insulin concentration occurred at somatostatin infusion of 200 ng.kg-1.min-1. Additional studies in anesthetized dogs demonstrated that somatostatin could suppress bile secretion without altering hepatic blood flow.

Original languageEnglish (US)
Pages (from-to)130-137
Number of pages8
JournalGastroenterology
Volume84
Issue number1
StatePublished - 1983
Externally publishedYes

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Somatostatin
Bile
Canidae
Fasting
Bile Acids and Salts
Erythritol
Dogs
Lipids
Taurocholic Acid
Bicarbonates
Gastric Mucosa
Hypothalamus
Chlorides
Pancreas
Insulin
Peptides
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hanks, J. B., Kortz, W. J., Andersen, D. K., & Jones, R. S. (1983). Somatostatin suppression of canine fasting bile secretion. Gastroenterology, 84(1), 130-137.

Somatostatin suppression of canine fasting bile secretion. / Hanks, J. B.; Kortz, W. J.; Andersen, D. K.; Jones, R. S.

In: Gastroenterology, Vol. 84, No. 1, 1983, p. 130-137.

Research output: Contribution to journalArticle

Hanks, JB, Kortz, WJ, Andersen, DK & Jones, RS 1983, 'Somatostatin suppression of canine fasting bile secretion', Gastroenterology, vol. 84, no. 1, pp. 130-137.
Hanks JB, Kortz WJ, Andersen DK, Jones RS. Somatostatin suppression of canine fasting bile secretion. Gastroenterology. 1983;84(1):130-137.
Hanks, J. B. ; Kortz, W. J. ; Andersen, D. K. ; Jones, R. S. / Somatostatin suppression of canine fasting bile secretion. In: Gastroenterology. 1983 ; Vol. 84, No. 1. pp. 130-137.
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