Somatofugal axonal atrophy precedes development of axonal degeneration in acrylamide neuropathy

Bruce G. Gold, John W. Griffin, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Somatofugal axonal atrophy is part of the neuronal perikaryal response to axonal injury (axon reaction). Chronic administration of acrylamide (AC) produces proximal atrophy in virtually all sensory fibers in lumbar dorsal root ganglion (DRG) despite the presence of many intact axons in the distal portion of the sciatic nerve. This suggests that the development of axonal atrophy in AC-intoxicated animals is not solely due to a toxic chemical-induced axonal degeneration (axotomy). In this study, we asked whether axonal atrophy arises before onset of axonal degeneration. Rats were given a single intraperitoneal (i.p.) high dose of AC (75 mg/kg), which blocks retrograde axonal transport, followed by daily intraperitoneal injections (30 mg/kg, for 4 days). At 5 days, sensory fibers in the L4 and L5 DRG appeared smaller in caliber and less circular in shape compared to fibers from age-matched normal animals. Axonal diameters of sensory fibers in the L5 dorsal root were significantly (p

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalArchives of Toxicology
Volume66
Issue number1
DOIs
StatePublished - Jan 1992

Fingerprint

Acrylamide
Atrophy
Fibers
Spinal Ganglia
Animals
Retrograde Degeneration
Axotomy
Axonal Transport
Spinal Nerve Roots
Poisons
Sciatic Nerve
Intraperitoneal Injections
Axons
Rats
Wounds and Injuries

Keywords

  • Acrylamide
  • Axon reaction
  • Axonal caliber
  • Neurofilaments
  • Neuronal perikaryon

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Somatofugal axonal atrophy precedes development of axonal degeneration in acrylamide neuropathy. / Gold, Bruce G.; Griffin, John W.; Price, Donald L.

In: Archives of Toxicology, Vol. 66, No. 1, 01.1992, p. 57-66.

Research output: Contribution to journalArticle

Gold, Bruce G. ; Griffin, John W. ; Price, Donald L. / Somatofugal axonal atrophy precedes development of axonal degeneration in acrylamide neuropathy. In: Archives of Toxicology. 1992 ; Vol. 66, No. 1. pp. 57-66.
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