Somatic tissue responses of male rhesus monkeys treated with a contraceptive steroid formulation

L. L. Ewing; A. C. Huber; J. D. Strandberg; R. J. Adams; R. C. Cochran; C. Desjardins

doi:10.1016/S0010-7824(83)80016-X

Somatic tissue responses of male rhesus monkeys treated with a contraceptive steroid formulation

L. L. Ewing, A. C. Huber, J. D. Strandberg, R. J. Adams, R. C. Cochran, C. Desjardins

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Rhesus monkeys (Macaca mulatta) were treated with testosterone (100 μg/kg/day) plus estradiol (0.5 μ/kg/day) via subcutaneous polydimethylsiloxane (PDS; Silastic) implants for thirteen months. This steroid regimen inhibited dramatically spermatogenesis. Gross and histopathological examination of the musculoskeletal, circulatory, endocrine (excluding the testis), central nervous, gastrointestinal and respiratory systems failed to uncover any untoward effects of the long-term exposure due to the contraceptive formulation. Similarly, no remarkable effects were observed in the ionic, chemical and formed elements of blood or secondary sex structures. Failure to detect secondary complications attributed to the steroid treatment offers further justification for evaluating a contraceptive strategy based on administering naturally occurring steroids at sustained rates approximating those at which they are produced endogenously in the human male.

Original language	English (US)
Pages (from-to)	363-381
Number of pages	19
Journal	Contraception
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/S0010-7824(83)80016-X
State	Published - Apr 1983
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/S0010-7824(83)80016-X

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title = "Somatic tissue responses of male rhesus monkeys treated with a contraceptive steroid formulation",

abstract = "Rhesus monkeys (Macaca mulatta) were treated with testosterone (100 μg/kg/day) plus estradiol (0.5 μ/kg/day) via subcutaneous polydimethylsiloxane (PDS; Silastic) implants for thirteen months. This steroid regimen inhibited dramatically spermatogenesis. Gross and histopathological examination of the musculoskeletal, circulatory, endocrine (excluding the testis), central nervous, gastrointestinal and respiratory systems failed to uncover any untoward effects of the long-term exposure due to the contraceptive formulation. Similarly, no remarkable effects were observed in the ionic, chemical and formed elements of blood or secondary sex structures. Failure to detect secondary complications attributed to the steroid treatment offers further justification for evaluating a contraceptive strategy based on administering naturally occurring steroids at sustained rates approximating those at which they are produced endogenously in the human male.",

author = "Ewing, {L. L.} and Huber, {A. C.} and Strandberg, {J. D.} and Adams, {R. J.} and Cochran, {R. C.} and C. Desjardins",

note = "Funding Information: The assistance of ...M. r. Be'e Pearson and Donald Carroll iS in part by the opmen through Research Contract tion Center 6ran 06268. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1983",

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doi = "10.1016/S0010-7824(83)80016-X",

language = "English (US)",

volume = "27",

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T1 - Somatic tissue responses of male rhesus monkeys treated with a contraceptive steroid formulation

AU - Ewing, L. L.

AU - Huber, A. C.

AU - Strandberg, J. D.

AU - Adams, R. J.

AU - Cochran, R. C.

AU - Desjardins, C.

N1 - Funding Information: The assistance of ...M. r. Be'e Pearson and Donald Carroll iS in part by the opmen through Research Contract tion Center 6ran 06268. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1983/4

Y1 - 1983/4

N2 - Rhesus monkeys (Macaca mulatta) were treated with testosterone (100 μg/kg/day) plus estradiol (0.5 μ/kg/day) via subcutaneous polydimethylsiloxane (PDS; Silastic) implants for thirteen months. This steroid regimen inhibited dramatically spermatogenesis. Gross and histopathological examination of the musculoskeletal, circulatory, endocrine (excluding the testis), central nervous, gastrointestinal and respiratory systems failed to uncover any untoward effects of the long-term exposure due to the contraceptive formulation. Similarly, no remarkable effects were observed in the ionic, chemical and formed elements of blood or secondary sex structures. Failure to detect secondary complications attributed to the steroid treatment offers further justification for evaluating a contraceptive strategy based on administering naturally occurring steroids at sustained rates approximating those at which they are produced endogenously in the human male.

AB - Rhesus monkeys (Macaca mulatta) were treated with testosterone (100 μg/kg/day) plus estradiol (0.5 μ/kg/day) via subcutaneous polydimethylsiloxane (PDS; Silastic) implants for thirteen months. This steroid regimen inhibited dramatically spermatogenesis. Gross and histopathological examination of the musculoskeletal, circulatory, endocrine (excluding the testis), central nervous, gastrointestinal and respiratory systems failed to uncover any untoward effects of the long-term exposure due to the contraceptive formulation. Similarly, no remarkable effects were observed in the ionic, chemical and formed elements of blood or secondary sex structures. Failure to detect secondary complications attributed to the steroid treatment offers further justification for evaluating a contraceptive strategy based on administering naturally occurring steroids at sustained rates approximating those at which they are produced endogenously in the human male.

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JO - Contraception

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ER -

Somatic tissue responses of male rhesus monkeys treated with a contraceptive steroid formulation

Abstract

ASJC Scopus subject areas

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