Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin Wyatt McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L. Gokaslan, Gregory J Riggins, Jean Paul Wolinksy, Laura Delong Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

Research output: Contribution to journalArticle

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original languageEnglish (US)
Pages (from-to)1170-1172
Number of pages3
JournalNature Genetics
Volume46
Issue number11
DOIs
StatePublished - Nov 1 2014

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Neurilemmoma
Neurofibroma
Mutation
Neurofibromatosis 1
Genome

ASJC Scopus subject areas

  • Medicine(all)

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Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. / Zhang, Ming; Wang, Yuxuan; Jones, Sian; Sausen, Mark; McMahon, Kevin Wyatt; Sharma, Rajni; Wang, Qing; Belzberg, Allan J; Chaichana, Kaisorn; Gallia, Gary L; Gokaslan, Ziya L.; Riggins, Gregory J; Wolinksy, Jean Paul; Wood, Laura Delong; Montgomery, Elizabeth A; Hruban, Ralph H; Kinzler, Kenneth W; Papadopoulos, Nickolas; Vogelstein, Bert; Bettegowda, Chetan.

In: Nature Genetics, Vol. 46, No. 11, 01.11.2014, p. 1170-1172.

Research output: Contribution to journalArticle

Zhang M, Wang Y, Jones S, Sausen M, McMahon KW, Sharma R et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nature Genetics. 2014 Nov 1;46(11):1170-1172. https://doi.org/10.1038/ng.3116
Zhang, Ming ; Wang, Yuxuan ; Jones, Sian ; Sausen, Mark ; McMahon, Kevin Wyatt ; Sharma, Rajni ; Wang, Qing ; Belzberg, Allan J ; Chaichana, Kaisorn ; Gallia, Gary L ; Gokaslan, Ziya L. ; Riggins, Gregory J ; Wolinksy, Jean Paul ; Wood, Laura Delong ; Montgomery, Elizabeth A ; Hruban, Ralph H ; Kinzler, Kenneth W ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan. / Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. In: Nature Genetics. 2014 ; Vol. 46, No. 11. pp. 1170-1172.
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