Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang; Yuxuan Wang; Sian Jones; Mark Sausen; Kevin Wyatt McMahon; Rajni Sharma; Qing Wang; Allan J Belzberg; Kaisorn Chaichana; Gary L Gallia; Ziya L. Gokaslan; Gregory J Riggins; Jean Paul Wolinksy; Laura Delong Wood; Elizabeth A Montgomery; Ralph H Hruban; Kenneth W Kinzler; Nickolas Papadopoulos; Bert Vogelstein; Chetan Bettegowda

doi:10.1038/ng.3116

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin Wyatt McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L. Gokaslan, Gregory J Riggins, Jean Paul Wolinksy, Laura Delong Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

School of Medicine

Research output: Contribution to journal › Article

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original language	English (US)
Pages (from-to)	1170-1172
Number of pages	3
Journal	Nature Genetics
Volume	46
Issue number	11
DOIs	https://doi.org/10.1038/ng.3116
State	Published - Nov 1 2014

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Medicine(all)

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Zhang, M., Wang, Y., Jones, S., Sausen, M., McMahon, K. W., Sharma, R., Wang, Q., Belzberg, A. J., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Riggins, G. J., Wolinksy, J. P., Wood, L. D., Montgomery, E. A., Hruban, R. H., Kinzler, K. W., Papadopoulos, N., Vogelstein, B., & Bettegowda, C. (2014). Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nature Genetics, 46(11), 1170-1172. https://doi.org/10.1038/ng.3116

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. / Zhang, Ming; Wang, Yuxuan; Jones, Sian; Sausen, Mark; McMahon, Kevin Wyatt; Sharma, Rajni; Wang, Qing; Belzberg, Allan J; Chaichana, Kaisorn; Gallia, Gary L; Gokaslan, Ziya L.; Riggins, Gregory J; Wolinksy, Jean Paul; Wood, Laura Delong ; Montgomery, Elizabeth A ; Hruban, Ralph H ; Kinzler, Kenneth W ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan.

In: Nature Genetics, Vol. 46, No. 11, 01.11.2014, p. 1170-1172.

Research output: Contribution to journal › Article

Zhang, M, Wang, Y, Jones, S, Sausen, M, McMahon, KW, Sharma, R, Wang, Q, Belzberg, AJ, Chaichana, K, Gallia, GL, Gokaslan, ZL, Riggins, GJ, Wolinksy, JP, Wood, LD , Montgomery, EA , Hruban, RH , Kinzler, KW , Papadopoulos, N , Vogelstein, B & Bettegowda, C 2014, 'Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors', Nature Genetics, vol. 46, no. 11, pp. 1170-1172. https://doi.org/10.1038/ng.3116

Zhang, Ming ; Wang, Yuxuan ; Jones, Sian ; Sausen, Mark ; McMahon, Kevin Wyatt ; Sharma, Rajni ; Wang, Qing ; Belzberg, Allan J ; Chaichana, Kaisorn ; Gallia, Gary L ; Gokaslan, Ziya L. ; Riggins, Gregory J ; Wolinksy, Jean Paul ; Wood, Laura Delong ; Montgomery, Elizabeth A ; Hruban, Ralph H ; Kinzler, Kenneth W ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan. / Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. In: Nature Genetics. 2014 ; Vol. 46, No. 11. pp. 1170-1172.

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