Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin Wyatt McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L. Gokaslan, Gregory J Riggins, Jean Paul Wolinksy, Laura Delong Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

Research output: Contribution to journalArticle

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original languageEnglish (US)
Pages (from-to)1170-1172
Number of pages3
JournalNature Genetics
Volume46
Issue number11
DOIs
StatePublished - Nov 1 2014

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ASJC Scopus subject areas

  • Medicine(all)

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