Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang; Yuxuan Wang; Sian Jones; Mark Sausen; Kevin McMahon; Rajni Sharma; Qing Wang; Allan J. Belzberg; Kaisorn Chaichana; Gary L. Gallia; Ziya L. Gokaslan; Greg J. Riggins; Jean Paul Wolinksy; Laura D. Wood; Elizabeth A. Montgomery; Ralph H. Hruban; Kenneth W. Kinzler; Nickolas Papadopoulos; Bert Vogelstein; Chetan Bettegowda

doi:10.1038/ng.3116

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin McMahon, Rajni Sharma, Qing Wang, Allan J. Belzberg, Kaisorn Chaichana, Gary L. Gallia, Ziya L. Gokaslan, Greg J. Riggins, Jean Paul Wolinksy, Laura D. Wood, Elizabeth A. Montgomery, Ralph H. Hruban, Kenneth W. Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original language	English (US)
Pages (from-to)	1170-1172
Number of pages	3
Journal	Nature genetics
Volume	46
Issue number	11
DOIs	https://doi.org/10.1038/ng.3116
State	Published - Nov 5 2014

ASJC Scopus subject areas

Genetics

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Zhang, M., Wang, Y., Jones, S., Sausen, M., McMahon, K., Sharma, R., Wang, Q., Belzberg, A. J., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Riggins, G. J., Wolinksy, J. P., Wood, L. D., Montgomery, E. A., Hruban, R. H., Kinzler, K. W., Papadopoulos, N., Vogelstein, B., & Bettegowda, C. (2014). Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nature genetics, 46(11), 1170-1172. https://doi.org/10.1038/ng.3116

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. / Zhang, Ming; Wang, Yuxuan; Jones, Sian; Sausen, Mark; McMahon, Kevin; Sharma, Rajni; Wang, Qing; Belzberg, Allan J.; Chaichana, Kaisorn; Gallia, Gary L.; Gokaslan, Ziya L.; Riggins, Greg J.; Wolinksy, Jean Paul; Wood, Laura D.; Montgomery, Elizabeth A.; Hruban, Ralph H.; Kinzler, Kenneth W.; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan.

In: Nature genetics, Vol. 46, No. 11, 05.11.2014, p. 1170-1172.

Research output: Contribution to journal › Article › peer-review

Zhang, M, Wang, Y, Jones, S, Sausen, M, McMahon, K, Sharma, R, Wang, Q, Belzberg, AJ, Chaichana, K, Gallia, GL, Gokaslan, ZL, Riggins, GJ, Wolinksy, JP, Wood, LD, Montgomery, EA, Hruban, RH , Kinzler, KW , Papadopoulos, N , Vogelstein, B & Bettegowda, C 2014, 'Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors', Nature genetics, vol. 46, no. 11, pp. 1170-1172. https://doi.org/10.1038/ng.3116

Zhang, Ming ; Wang, Yuxuan ; Jones, Sian ; Sausen, Mark ; McMahon, Kevin ; Sharma, Rajni ; Wang, Qing ; Belzberg, Allan J. ; Chaichana, Kaisorn ; Gallia, Gary L. ; Gokaslan, Ziya L. ; Riggins, Greg J. ; Wolinksy, Jean Paul ; Wood, Laura D. ; Montgomery, Elizabeth A. ; Hruban, Ralph H. ; Kinzler, Kenneth W. ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan. / Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. In: Nature genetics. 2014 ; Vol. 46, No. 11. pp. 1170-1172.

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title = "Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors",

abstract = "Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.",

author = "Ming Zhang and Yuxuan Wang and Sian Jones and Mark Sausen and Kevin McMahon and Rajni Sharma and Qing Wang and Belzberg, {Allan J.} and Kaisorn Chaichana and Gallia, {Gary L.} and Gokaslan, {Ziya L.} and Riggins, {Greg J.} and Wolinksy, {Jean Paul} and Wood, {Laura D.} and Montgomery, {Elizabeth A.} and Hruban, {Ralph H.} and Kinzler, {Kenneth W.} and Nickolas Papadopoulos and Bert Vogelstein and Chetan Bettegowda",

note = "Funding Information: We thank our patients for their courage and generosity. We also thank J. Ptak, N. Silliman, L. Dobbyn, J. Schaeffer and M. Papoli for expert technical assistance. The work was supported by the Virginia and D.K. Ludwig Fund for Cancer Research, a Burroughs Wellcome Career Award for Medical Scientists, a Johns Hopkins Clinical Scientist Award and grant 2014107 from the Doris Duke Charitable Foundation.",

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AU - Wang, Qing

AU - Belzberg, Allan J.

AU - Chaichana, Kaisorn

AU - Gallia, Gary L.

AU - Gokaslan, Ziya L.

AU - Riggins, Greg J.

AU - Wolinksy, Jean Paul

AU - Wood, Laura D.

AU - Montgomery, Elizabeth A.

AU - Hruban, Ralph H.

AU - Kinzler, Kenneth W.

AU - Papadopoulos, Nickolas

AU - Vogelstein, Bert

AU - Bettegowda, Chetan

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N2 - Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

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