Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin Wyatt McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L. Gokaslan, Gregory J Riggins, Jean Paul Wolinksy, Laura Delong Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

Research output: Contribution to journal › Article

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original languageEnglish (US)
Pages (from-to)1170-1172
Number of pages3
JournalNature Genetics
Volume46
Issue number11
DOIs
StatePublished - Nov 1 2014

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Neurilemmoma
Neurofibroma
Mutation
Neurofibromatosis 1
Genome

ASJC Scopus subject areas

  • Medicine(all)

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Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. / Zhang, Ming; Wang, Yuxuan; Jones, Sian; Sausen, Mark; McMahon, Kevin Wyatt; Sharma, Rajni; Wang, Qing; Belzberg, Allan J; Chaichana, Kaisorn; Gallia, Gary L; Gokaslan, Ziya L.; Riggins, Gregory J; Wolinksy, Jean Paul; Wood, Laura Delong; Montgomery, Elizabeth A; Hruban, Ralph H; Kinzler, Kenneth W; Papadopoulos, Nickolas; Vogelstein, Bert; Bettegowda, Chetan.

In: Nature Genetics, Vol. 46, No. 11, 01.11.2014, p. 1170-1172.

Research output: Contribution to journal › Article

Zhang, M, Wang, Y, Jones, S, Sausen, M, McMahon, KW, Sharma, R, Wang, Q, Belzberg, AJ, Chaichana, K, Gallia, GL, Gokaslan, ZL, Riggins, GJ, Wolinksy, JP, Wood, LD, Montgomery, EA, Hruban, RH, Kinzler, KW, Papadopoulos, N, Vogelstein, B & Bettegowda, C 2014, 'Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors', Nature Genetics, vol. 46, no. 11, pp. 1170-1172. https://doi.org/10.1038/ng.3116
Zhang M, Wang Y, Jones S, Sausen M, McMahon KW, Sharma R et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nature Genetics. 2014 Nov 1;46(11):1170-1172. https://doi.org/10.1038/ng.3116
Zhang, Ming ; Wang, Yuxuan ; Jones, Sian ; Sausen, Mark ; McMahon, Kevin Wyatt ; Sharma, Rajni ; Wang, Qing ; Belzberg, Allan J ; Chaichana, Kaisorn ; Gallia, Gary L ; Gokaslan, Ziya L. ; Riggins, Gregory J ; Wolinksy, Jean Paul ; Wood, Laura Delong ; Montgomery, Elizabeth A ; Hruban, Ralph H ; Kinzler, Kenneth W ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Bettegowda, Chetan. / Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. In: Nature Genetics. 2014 ; Vol. 46, No. 11. pp. 1170-1172.
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