@article{3104e68504e3425dbc78e8548cdca6e5,
title = "Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors",
abstract = "Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.",
author = "Ming Zhang and Yuxuan Wang and Sian Jones and Mark Sausen and McMahon, {Kevin Wyatt} and Rajni Sharma and Qing Wang and Belzberg, {Allan J.} and Kaisorn Chaichana and Gallia, {Gary L.} and Gokaslan, {Ziya L} and Riggins, {Greg J.} and Wolinksy, {Jean Paul} and Wood, {Laura D.} and Montgomery, {Elizabeth A} and Hruban, {Ralph H.} and Kinzler, {Kenneth W.} and Nickolas Papadopoulos and Bert Vogelstein and Chetan Bettegowda",
note = "Funding Information: We thank our patients for their courage and generosity. We also thank J. Ptak, N. Silliman, L. Dobbyn, J. Schaeffer and M. Papoli for expert technical assistance. The work was supported by the Virginia and D.K. Ludwig Fund for Cancer Research, a Burroughs Wellcome Career Award for Medical Scientists, a Johns Hopkins Clinical Scientist Award and grant 2014107 from the Doris Duke Charitable Foundation. Publisher Copyright: {\textcopyright} 2014 Nature America, Inc. All rights reserved.",
year = "2014",
month = nov,
day = "5",
doi = "10.1038/ng.3116",
language = "English (US)",
volume = "46",
pages = "1170--1172",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}