TY - JOUR
T1 - Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers
AU - Jiao, Xiang
AU - Wood, Laura D.
AU - Lindman, Monica
AU - Jones, Sian
AU - Buckhaults, Phillip
AU - Polyak, Kornelia
AU - Sukumar, Saraswati
AU - Carter, Hannah
AU - Kim, Dewey
AU - Karchin, Rachel
AU - Sjöblom, Tobias
PY - 2012/5
Y1 - 2012/5
N2 - Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.
AB - Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.
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U2 - 10.1002/gcc.21935
DO - 10.1002/gcc.21935
M3 - Article
C2 - 22302350
AN - SCOPUS:84862818029
VL - 51
SP - 480
EP - 489
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
SN - 1045-2257
IS - 5
ER -