Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Xiang Jiao; Laura D. Wood; Monica Lindman; Sian Jones; Phillip Buckhaults; Kornelia Polyak; Saraswati Sukumar; Hannah Carter; Dewey Kim; Rachel Karchin; Tobias Sjöblom

doi:10.1002/gcc.21935

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Xiang Jiao, Laura D. Wood, Monica Lindman, Sian Jones, Phillip Buckhaults, Kornelia Polyak, Saraswati Sukumar, Hannah Carter, Dewey Kim, Rachel Karchin, Tobias Sjöblom

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.

Original language	English (US)
Pages (from-to)	480-489
Number of pages	10
Journal	Genes Chromosomes and Cancer
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/gcc.21935
State	Published - May 2012

ASJC Scopus subject areas

Genetics
Cancer Research

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10.1002/gcc.21935

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Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers. / Jiao, Xiang; Wood, Laura D.; Lindman, Monica; Jones, Sian; Buckhaults, Phillip; Polyak, Kornelia; Sukumar, Saraswati; Carter, Hannah; Kim, Dewey; Karchin, Rachel; Sjöblom, Tobias.

In: Genes Chromosomes and Cancer, Vol. 51, No. 5, 05.2012, p. 480-489.

Research output: Contribution to journal › Article › peer-review

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abstract = "Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.",

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AU - Polyak, Kornelia

AU - Sukumar, Saraswati

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AB - Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.

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Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

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