Somatic hypermutation

subverted DNA repair

Stella A. Martomo, Patricia J. Gearhart

Research output: Contribution to journalArticle

Abstract

Somatic hypermutation generates high-affinity antibodies of different isotypes that efficiently protect us against a plethora of pathogens. Recent analyses of the types of mutations produced in gene-deficient mice have indicated how DNA repair proteins are drawn into the pathway. Activation-induced cytosine deaminase begins the process by deaminating cytosine to uracil in DNA. The uracils are then recognized by the base excision repair protein uracil DNA glycosylase and by the mismatch repair proteins MutS homologue 2 and MutS homologue 6. Instead of repairing the uracils, these proteins attract low fidelity DNA polymerases, which synthesize nucleotide substitutions at an unprecedented level.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalCurrent Opinion in Immunology
Volume18
Issue number3
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Uracil
DNA Repair
MutS DNA Mismatch-Binding Protein
Cytosine Deaminase
Uracil-DNA Glycosidase
Proteins
Antibody Affinity
Cytosine
DNA-Directed DNA Polymerase
Nucleotides
Mutation
DNA
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Somatic hypermutation : subverted DNA repair. / Martomo, Stella A.; Gearhart, Patricia J.

In: Current Opinion in Immunology, Vol. 18, No. 3, 06.2006, p. 243-248.

Research output: Contribution to journalArticle

Martomo, Stella A. ; Gearhart, Patricia J. / Somatic hypermutation : subverted DNA repair. In: Current Opinion in Immunology. 2006 ; Vol. 18, No. 3. pp. 243-248.
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