Somatic cell hybrid deletion map of human chromosome 18

Antonie D. Kline, Katherine Rojas, Reema Mewar, Deborah Moshinsky, Joan Overhauser

Research output: Contribution to journalArticle

Abstract

The creation of a physical map of chromosome 18 will be useful for the eventual identification of specific chromosomal regions that are critical in the occurrence of Edwards syndrome, the 18q-syndrome, and the 18p-syndrome. To begin the investigation of these syndromes, a physical map has been constructed to order random DNA fragments to specific portions of chromosome 18. A set of somatic cell hybrids that retain deletions or translocations involving chromosome 18 has been isolated and characterized. Over 200 lambda phage from a chromosome 18-specific library have been localized to 11 distinct regions of chromosome 18 using the chromosomal breakpoints present in the somatic cell hybrids.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalGenomics
Volume13
Issue number1
DOIs
StatePublished - May 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Kline, A. D., Rojas, K., Mewar, R., Moshinsky, D., & Overhauser, J. (1992). Somatic cell hybrid deletion map of human chromosome 18. Genomics, 13(1), 1-6. https://doi.org/10.1016/0888-7543(92)90193-V