Somatic cell hybrid deletion map of human chromosome 18

Antonie Debra Kline, Katherine Rojas, Reema Mewar, Deborah Moshinsky, Joan Overhauser

Research output: Contribution to journalArticle

Abstract

The creation of a physical map of chromosome 18 will be useful for the eventual identification of specific chromosomal regions that are critical in the occurrence of Edwards syndrome, the 18q-syndrome, and the 18p-syndrome. To begin the investigation of these syndromes, a physical map has been constructed to order random DNA fragments to specific portions of chromosome 18. A set of somatic cell hybrids that retain deletions or translocations involving chromosome 18 has been isolated and characterized. Over 200 lambda phage from a chromosome 18-specific library have been localized to 11 distinct regions of chromosome 18 using the chromosomal breakpoints present in the somatic cell hybrids.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalGenomics
Volume13
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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Chromosomes, Human, Pair 18
Hybrid Cells
Human Chromosomes
Bacteriophage lambda
Libraries
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Kline, A. D., Rojas, K., Mewar, R., Moshinsky, D., & Overhauser, J. (1992). Somatic cell hybrid deletion map of human chromosome 18. Genomics, 13(1), 1-6. https://doi.org/10.1016/0888-7543(92)90193-V

Somatic cell hybrid deletion map of human chromosome 18. / Kline, Antonie Debra; Rojas, Katherine; Mewar, Reema; Moshinsky, Deborah; Overhauser, Joan.

In: Genomics, Vol. 13, No. 1, 1992, p. 1-6.

Research output: Contribution to journalArticle

Kline, AD, Rojas, K, Mewar, R, Moshinsky, D & Overhauser, J 1992, 'Somatic cell hybrid deletion map of human chromosome 18', Genomics, vol. 13, no. 1, pp. 1-6. https://doi.org/10.1016/0888-7543(92)90193-V
Kline, Antonie Debra ; Rojas, Katherine ; Mewar, Reema ; Moshinsky, Deborah ; Overhauser, Joan. / Somatic cell hybrid deletion map of human chromosome 18. In: Genomics. 1992 ; Vol. 13, No. 1. pp. 1-6.
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