Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats

Chao Qin; Jiande D.Z. Chen; Jing Zhang; Robert D. Foreman

doi:10.1111/j.1525-1403.2009.00258.x

Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats

Chao Qin, Jiande D.Z. Chen, Jing Zhang, Robert D. Foreman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objectives: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. Materials and Methods: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. Results: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). Conclusions: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.

Original language	English (US)
Pages (from-to)	77-86
Number of pages	10
Journal	Neuromodulation
Volume	13
Issue number	2
DOIs	https://doi.org/10.1111/j.1525-1403.2009.00258.x
State	Published - Apr 2010
Externally published	Yes

Keywords

Extracellular recording
Nerve stimulation
Neuromodulation
Spinal cord
Visceral pain

ASJC Scopus subject areas

Neurology
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1111/j.1525-1403.2009.00258.x

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title = "Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats",

abstract = "Objectives: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. Materials and Methods: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. Results: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). Conclusions: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.",

keywords = "Extracellular recording, Nerve stimulation, Neuromodulation, Spinal cord, Visceral pain",

author = "Chao Qin and Chen, {Jiande D.Z.} and Jing Zhang and Foreman, {Robert D.}",

year = "2010",

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doi = "10.1111/j.1525-1403.2009.00258.x",

language = "English (US)",

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AU - Qin, Chao

AU - Chen, Jiande D.Z.

AU - Zhang, Jing

AU - Foreman, Robert D.

PY - 2010/4

Y1 - 2010/4

N2 - Objectives: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. Materials and Methods: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. Results: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). Conclusions: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.

AB - Objectives: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. Materials and Methods: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. Results: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). Conclusions: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.

KW - Extracellular recording

KW - Nerve stimulation

KW - Neuromodulation

KW - Spinal cord

KW - Visceral pain

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Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats

Abstract

Keywords

ASJC Scopus subject areas

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