Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats

Chao Qin, Jiande D.Z. Chen, Jing Zhang, Robert D. Foreman

Research output: Contribution to journalArticle

Abstract

Objectives: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. Materials and Methods: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. Results: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). Conclusions: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.

Original languageEnglish (US)
Pages (from-to)77-86
Number of pages10
JournalNeuromodulation
Volume13
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

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Keywords

  • Extracellular recording
  • Nerve stimulation
  • Neuromodulation
  • Spinal cord
  • Visceral pain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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