Soluble tumor-associated markers in lung cancer extracts

Peter E. Maxim, Robert W. Veltri, Philip M. Sprinkle

Research output: Contribution to journalArticle

Abstract

Three lung tumor-associated markers (LTAM), previously identified as a Cohn Fraction IV α-globulin (LTAM-1), ferritin (LTAM-2) and lactoferrin (LTAM-3) were separated by a combination of ion exchange, dye-affinity and molecular sieve chromatography. They were further purified by polyacrylamide gel electrophoresis and antisera were raised. Analysis of human extracts by immunodiffusion showed that 80% of lung tumor extracts were positive for all three markers. Similarly, 70% of extracts from other tumors were positive for LTAM 1, but only 10% of these extracts were positive for LTAM 2 and 3. Variation in concentration of LTAM 2 and 3 among several extracts was determined by a quantitative enzyme immunoassay. Analysis of a select group of extracts for carcinoembryonic antigen (CEA), α-fetoprotein and β2-microglobulin showed 50% of these extracts to have markedly elevated levels of CEA. The results suggest that ferritin, lactoferrin and CEA offer promise as markers fo.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalOncology (Switzerland)
Volume38
Issue number3
DOIs
StatePublished - Jan 1 1981

Keywords

  • Ferritin
  • Lactoferrin
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Soluble tumor-associated markers in lung cancer extracts'. Together they form a unique fingerprint.

  • Cite this

    Maxim, P. E., Veltri, R. W., & Sprinkle, P. M. (1981). Soluble tumor-associated markers in lung cancer extracts. Oncology (Switzerland), 38(3), 147-153. https://doi.org/10.1159/000225542