Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: A prognostic marker for lung metastases from solid malignancies

Eleni M. Karapanagiotou, Emilia Pelekanou, Adrianni Charpidou, Thomas Tsaganos, Valsamo Anagnostou, Diamantis Plachouras, Evangelos J. Giamarellos-Bourboulis, Kostas N. Syrigos

Research output: Contribution to journalArticle

Abstract

The aim of the study was to evaluate the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in breast, lung and colorectal cancer patients in correlation with clinical variables. Patients and Methods: A total of 59 patients with a median age of 64 years and histologically confirmed breast 14, colorectal 15 or lung cancer 30 were evaluated. Five patients with breast cancer, 7 patients with colorectal cancer and 8 patients with lung cancer had lung metastases. Blood was collected upon enrolment, centrifuged and the serum kept at -80°C until assayed for sTREM-1. The estimation of sTREM-1 was performed by a crude enzyme immunoabsorbent assay. Results: High levels of sTREM-1 were observed in 50% of breast cancer, 33.3% of Small Cell Lung carcinoma (SCLC), 26.7% of colorectal cancer and 13.3% of Non Small Cell Lung Carcinoma (NSCLC) patients. sTREM-1 expression showed a correlation to the site of metastases. Higher concentrations were observed in the absence of lung metastases (p=0.019). Discussion: The novel mediator sTREM-1 may be a prognostic marker for the detection of lung metastases in metastatic and locally advanced solid tumors.

Original languageEnglish (US)
Pages (from-to)1411-1415
Number of pages5
JournalAnticancer Research
Volume28
Issue number2 B
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Lung metastasis
  • Prognostic marker
  • s-TREM-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Karapanagiotou, E. M., Pelekanou, E., Charpidou, A., Tsaganos, T., Anagnostou, V., Plachouras, D., Giamarellos-Bourboulis, E. J., & Syrigos, K. N. (2008). Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: A prognostic marker for lung metastases from solid malignancies. Anticancer Research, 28(2 B), 1411-1415.