Soluble serum interleukin 2 receptor levels in leprosy patients

K. S K Tung, E. Umland, P. Matzner, Kenrad Edwin Nelson, V. Schauf, L. Rubin, D. Wagner, D. Scollard, P. Vithayasai, V. Vithayasai

Research output: Contribution to journalArticle

Abstract

Soluble interleukin 2 receptors (IL-2R) in sera of leprosy patients from Chiang Mai, Thailand, were quantified with a solid phase enzyme immunoassay using two monoclonal antibodies to the IL-2R. The IL-2R levels of untreated lepromatous, borderline lepromatous or midborderline patients and treated lepromatous and borderline lepromatous or treated borderline tuberculoid and tuberculoid patients were comparable to those of the Thai household or nonhousehold contacts; and they were significantly higher than the levels of USA control subjects. In contrast, IL-2R of untreated tuberculoid or borderline tuberculoid patients were significantly reduced. Patients with ongoing reversal reaction had very high circulating IL-2R, the levels of which correlated with fever and extent of skin lesions. Although erythema nodosum leprosum patients also had elevated IL-2R levels, they were significantly below those of patients with reversal reaction. When treated with corticosteroid, precipitous reduction of IL-2R was noted in all patients with reversal reaction but not in patients with erythema nodosum leprosum.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalClinical and Experimental Immunology
Volume69
Issue number1
StatePublished - 1987
Externally publishedYes

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Interleukin-2 Receptors
Leprosy
Serum
Multibacillary Leprosy
Paucibacillary Leprosy
Erythema Nodosum
Thailand
Immunoenzyme Techniques
Adrenal Cortex Hormones
Fever
Monoclonal Antibodies
Skin

ASJC Scopus subject areas

  • Immunology

Cite this

Tung, K. S. K., Umland, E., Matzner, P., Nelson, K. E., Schauf, V., Rubin, L., ... Vithayasai, V. (1987). Soluble serum interleukin 2 receptor levels in leprosy patients. Clinical and Experimental Immunology, 69(1), 10-15.

Soluble serum interleukin 2 receptor levels in leprosy patients. / Tung, K. S K; Umland, E.; Matzner, P.; Nelson, Kenrad Edwin; Schauf, V.; Rubin, L.; Wagner, D.; Scollard, D.; Vithayasai, P.; Vithayasai, V.

In: Clinical and Experimental Immunology, Vol. 69, No. 1, 1987, p. 10-15.

Research output: Contribution to journalArticle

Tung, KSK, Umland, E, Matzner, P, Nelson, KE, Schauf, V, Rubin, L, Wagner, D, Scollard, D, Vithayasai, P & Vithayasai, V 1987, 'Soluble serum interleukin 2 receptor levels in leprosy patients', Clinical and Experimental Immunology, vol. 69, no. 1, pp. 10-15.
Tung KSK, Umland E, Matzner P, Nelson KE, Schauf V, Rubin L et al. Soluble serum interleukin 2 receptor levels in leprosy patients. Clinical and Experimental Immunology. 1987;69(1):10-15.
Tung, K. S K ; Umland, E. ; Matzner, P. ; Nelson, Kenrad Edwin ; Schauf, V. ; Rubin, L. ; Wagner, D. ; Scollard, D. ; Vithayasai, P. ; Vithayasai, V. / Soluble serum interleukin 2 receptor levels in leprosy patients. In: Clinical and Experimental Immunology. 1987 ; Vol. 69, No. 1. pp. 10-15.
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