Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain

Victor L. Serebruany, Selva R. Murugesan, Anitha Pothula, Husam Semaan, Paul A. Gurbel

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to determine plasma levels of platelet/endothelial cell adhesion molecule-1 (PECAM-1), P-selectin, acid platelet-derived osteonectin, and prospectively compare these data with the discharge diagnosis in patients presenting with chest pain in a community hospital Emergency Department. Soluble antigens were measured by ELISA in 44 subjects including patients with acute myocardial infarction (AMI) (n = 13), chest pain of noncardiac origin (n = 17), and compared to those of age- and sex-matched healthy controls (n = 14). Elevated soluble PECAM-1 (64.5 ± 18.3 ng/ml, p = 0.019), but not P-selectin (149.5 ± 49.8 ng/ml, p = NS), nor osteonectin (549.5 ± 159.1 ng/ml, p = NS), occurred in the AMI group as compared to patients with noncardiac chest pain (46.2 ± 7.5 ng/ml, 118.2 ± 40.1 ng/ml, and 619.4 ± 74.4 ng/ml, respectively). Increased plasma PECAM-1 may serve as a useful marker in the early detection of patients with AMI. Larger studies will be necessary to confirm the utility of soluble PECAM-1 in identifying AMI among patients presenting with chest pain.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalCardiology
Volume91
Issue number1
DOIs
StatePublished - Jun 26 1999

Keywords

  • Acute myocardial infarction
  • Chest pain
  • Emergency medicine
  • Osteonectin
  • P-selectin
  • PECAM-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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