Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults

N. S. Jenny, A. M. Arnold, L. H. Kuller, A. R. Sharrett, L. P. Fried, B. M. Psaty, Russell P. Tracy

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression. Objectives: We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age ≥65 years) from the Cardiovascular Health Study. Meth ods: Selected participants were free of clinical CVD at baseline. Nonexclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n - 842; CVD death = 310). A total 643 subjects were free of events during follow-up. Results: sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events. Conclusions: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume4
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Cardiovascular disease
  • Death
  • Elderly
  • Intracellular adhesion molecule-1

ASJC Scopus subject areas

  • Hematology

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