Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women

Yamil Gerena, Raissa Menéndez-Delmestre, Richard L. Skolasky, Rosa M. Hechavarria, Sebastián Pérez, Claudia Hilera, Claribel González, Avindra Nath, Valerie Wojna

Research output: Contribution to journalArticle

Abstract

Insulin resistance occurs in HIV-infected individuals and is associated with HIV-associated neurocognitive disorders (HAND). However, the mechanisms involved are not well understood. Previously, we showed a correlation between soluble insulin receptor (sIR) and HAND. Here, we investigated if binding of free insulin to sIR and soluble insulin-like growth factor-1 receptor (sIGF1-R) levels are associated with sIR in HAND. Thirty-four (34) HIV-seropositive women stratified by cognitive status and five HIV-seronegative women were evaluated. In a subgroup of 20 HIV positive and 5 donors, binding of plasma insulin to sIR was determined by ELISA assay of residual insulin levels in plasma immuno-depleted with anti-IR-monoclonal antibody-Sepharose beads. sIR and sIGF1-R levels were determined by ELISA. Nonparametric statistics were used. Higher percentages of insulin bound to sIR significantly correlated with sIR levels and were associated with HAND status. Higher levels of plasma sIGF1-R had a positive correlation with sIR levels (p = 0.011) and were associated with HAND (p = 0.006). No correlations were observed with age, viral-immune profile, antiretroviral therapy, or TNF. This study suggests that changes in sIGF1-R levels and insulin binding to sIR may contribute to HAND.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalJournal of neurovirology
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • HIV-associated neurocognitive disorder
  • Insulin binding
  • Soluble insulin receptor
  • Soluble insulin-like growth factor-1 receptor
  • Women

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Fingerprint Dive into the research topics of 'Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women'. Together they form a unique fingerprint.

  • Cite this

    Gerena, Y., Menéndez-Delmestre, R., Skolasky, R. L., Hechavarria, R. M., Pérez, S., Hilera, C., González, C., Nath, A., & Wojna, V. (2015). Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women. Journal of neurovirology, 21(2), 113-119. https://doi.org/10.1007/s13365-014-0310-2