Soluble human epidermal growth factor receptor 2 (HER2) levels in patients with HER2-positive breast cancer receiving chemotherapy with or without trastuzumab: Results from North Central Cancer Treatment Group adjuvant trial N9831

Alvaro Moreno-Aspitia, David W. Hillman, Stephen H. Dyar, Kathleen S. Tenner, Julie Gralow, Peter A. Kaufman, Nancy E. Davidson, Jacqueline M. Lafky, Monica M. Reinholz, Wilma L. Lingle, Leila A. Kutteh, Walter P. Carney, Amylou C. Dueck, Edith A. Perez

Research output: Contribution to journalArticle

Abstract

BACKGROUND Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9831 clinical trial. METHODS The objectives were to describe sHER2 levels during treatment and at the time of recurrence in patients who were randomized to treatment arms A (standard chemotherapy), B (standard chemotherapy with sequential trastuzumab), and C (standard chemotherapy with concurrent trastuzumab). Baseline samples were available from 2318 patients, serial samples were available from 105 patients, and recurrence samples were available from 124 patients. The cutoff sHER2 value for the assay was 15 ng/mL. Statistical methods included repeated measures linear models, Wilcoxon rank-sum tests, and Cox regression models. RESULTS There were differences between groups in terms of age, menopausal status, and hormone receptor status. Within treatment arms A, B, and C, patients who had baseline sHER2 levels ≥15 ng/mL had worse disease-free survival than patients who had baseline sHER2 levels

Original languageEnglish (US)
Pages (from-to)2675-2682
Number of pages8
JournalCancer
Volume119
Issue number15
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Fingerprint

Breast Neoplasms
Drug Therapy
Neoplasms
Nonparametric Statistics
Recurrence
Therapeutics
Trastuzumab
human ERBB2 protein
Proportional Hazards Models
Disease-Free Survival
Linear Models
Clinical Trials
Hormones

Keywords

  • biomarker
  • breast cancer
  • extracellular domain
  • HER2-positive
  • human epidermal growth factor receptor 2
  • serum HER2

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Soluble human epidermal growth factor receptor 2 (HER2) levels in patients with HER2-positive breast cancer receiving chemotherapy with or without trastuzumab : Results from North Central Cancer Treatment Group adjuvant trial N9831. / Moreno-Aspitia, Alvaro; Hillman, David W.; Dyar, Stephen H.; Tenner, Kathleen S.; Gralow, Julie; Kaufman, Peter A.; Davidson, Nancy E.; Lafky, Jacqueline M.; Reinholz, Monica M.; Lingle, Wilma L.; Kutteh, Leila A.; Carney, Walter P.; Dueck, Amylou C.; Perez, Edith A.

In: Cancer, Vol. 119, No. 15, 01.08.2013, p. 2675-2682.

Research output: Contribution to journalArticle

Moreno-Aspitia, A, Hillman, DW, Dyar, SH, Tenner, KS, Gralow, J, Kaufman, PA, Davidson, NE, Lafky, JM, Reinholz, MM, Lingle, WL, Kutteh, LA, Carney, WP, Dueck, AC & Perez, EA 2013, 'Soluble human epidermal growth factor receptor 2 (HER2) levels in patients with HER2-positive breast cancer receiving chemotherapy with or without trastuzumab: Results from North Central Cancer Treatment Group adjuvant trial N9831', Cancer, vol. 119, no. 15, pp. 2675-2682. https://doi.org/10.1002/cncr.28130
Moreno-Aspitia, Alvaro ; Hillman, David W. ; Dyar, Stephen H. ; Tenner, Kathleen S. ; Gralow, Julie ; Kaufman, Peter A. ; Davidson, Nancy E. ; Lafky, Jacqueline M. ; Reinholz, Monica M. ; Lingle, Wilma L. ; Kutteh, Leila A. ; Carney, Walter P. ; Dueck, Amylou C. ; Perez, Edith A. / Soluble human epidermal growth factor receptor 2 (HER2) levels in patients with HER2-positive breast cancer receiving chemotherapy with or without trastuzumab : Results from North Central Cancer Treatment Group adjuvant trial N9831. In: Cancer. 2013 ; Vol. 119, No. 15. pp. 2675-2682.
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abstract = "BACKGROUND Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9831 clinical trial. METHODS The objectives were to describe sHER2 levels during treatment and at the time of recurrence in patients who were randomized to treatment arms A (standard chemotherapy), B (standard chemotherapy with sequential trastuzumab), and C (standard chemotherapy with concurrent trastuzumab). Baseline samples were available from 2318 patients, serial samples were available from 105 patients, and recurrence samples were available from 124 patients. The cutoff sHER2 value for the assay was 15 ng/mL. Statistical methods included repeated measures linear models, Wilcoxon rank-sum tests, and Cox regression models. RESULTS There were differences between groups in terms of age, menopausal status, and hormone receptor status. Within treatment arms A, B, and C, patients who had baseline sHER2 levels ≥15 ng/mL had worse disease-free survival than patients who had baseline sHER2 levels",
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T2 - Results from North Central Cancer Treatment Group adjuvant trial N9831

AU - Moreno-Aspitia, Alvaro

AU - Hillman, David W.

AU - Dyar, Stephen H.

AU - Tenner, Kathleen S.

AU - Gralow, Julie

AU - Kaufman, Peter A.

AU - Davidson, Nancy E.

AU - Lafky, Jacqueline M.

AU - Reinholz, Monica M.

AU - Lingle, Wilma L.

AU - Kutteh, Leila A.

AU - Carney, Walter P.

AU - Dueck, Amylou C.

AU - Perez, Edith A.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9831 clinical trial. METHODS The objectives were to describe sHER2 levels during treatment and at the time of recurrence in patients who were randomized to treatment arms A (standard chemotherapy), B (standard chemotherapy with sequential trastuzumab), and C (standard chemotherapy with concurrent trastuzumab). Baseline samples were available from 2318 patients, serial samples were available from 105 patients, and recurrence samples were available from 124 patients. The cutoff sHER2 value for the assay was 15 ng/mL. Statistical methods included repeated measures linear models, Wilcoxon rank-sum tests, and Cox regression models. RESULTS There were differences between groups in terms of age, menopausal status, and hormone receptor status. Within treatment arms A, B, and C, patients who had baseline sHER2 levels ≥15 ng/mL had worse disease-free survival than patients who had baseline sHER2 levels

AB - BACKGROUND Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9831 clinical trial. METHODS The objectives were to describe sHER2 levels during treatment and at the time of recurrence in patients who were randomized to treatment arms A (standard chemotherapy), B (standard chemotherapy with sequential trastuzumab), and C (standard chemotherapy with concurrent trastuzumab). Baseline samples were available from 2318 patients, serial samples were available from 105 patients, and recurrence samples were available from 124 patients. The cutoff sHER2 value for the assay was 15 ng/mL. Statistical methods included repeated measures linear models, Wilcoxon rank-sum tests, and Cox regression models. RESULTS There were differences between groups in terms of age, menopausal status, and hormone receptor status. Within treatment arms A, B, and C, patients who had baseline sHER2 levels ≥15 ng/mL had worse disease-free survival than patients who had baseline sHER2 levels

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