Soluble CD14: An independent biomarker for the risk of mother-to-child transmission of HIV in a setting of preexposure and postexposure antiretroviral prophylaxis

Rupak Shivakoti, Amita Gupta, Jocelyn C. Ray, Priyanka Uprety, Nikhil Gupte, Ramesh Bhosale, Vidya Mave, Sandesh Patil, Usha Balasubramanian, Aarti Kinikar, Renu Bharadwaj, Robert C. Bollinger, Deborah Persaud

Research output: Contribution to journalArticle

Abstract

Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of motherto- child transmission (MTCT) of HIV, we nested a case-control study (49 pairs of infants and their HIV-infected mothers) within the Six-Week Extended-Dose Nevirapine trial. Median peripartum maternal log2 sCD14 concentration was higher among transmitters (defined as pairs in which maternally transmitted HIV infection occurred by 12 months of age) than nontransmitters (20.29 pg/mL vs 19.41 pg/mL; P = .005). There was an increased odds of MTCT for every log2 increase in maternal sCD14 concentration, after adjustment for maternal HIV load, CD4 count and cART exposure (adjusted odds ratio, 3.51; 95% confidence interval, 1.21-10.21). Maternal monocyte activation may adversely influence the risk of MTCT of HIV.

Original languageEnglish (US)
Pages (from-to)762-765
Number of pages4
JournalJournal of Infectious Diseases
Volume212
Issue number11
DOIs
StatePublished - 2015

Keywords

  • HIV
  • Mother-to-child transmission
  • sCD14

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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