Soluble benzodiazepine receptors: Gabaergic regulation

Moshe Gavish, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

Original languageEnglish (US)
Pages (from-to)579-582
Number of pages4
JournalLife Sciences
Volume26
Issue number8
DOIs
StatePublished - Feb 25 1980

Fingerprint

GABA-A Receptors
GABA Antagonists
Flunitrazepam
Bicuculline
gamma-Aminobutyric Acid
Brain
Ligands
Membranes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Soluble benzodiazepine receptors : Gabaergic regulation. / Gavish, Moshe; Snyder, Solomon H.

In: Life Sciences, Vol. 26, No. 8, 25.02.1980, p. 579-582.

Research output: Contribution to journalArticle

Gavish, Moshe ; Snyder, Solomon H. / Soluble benzodiazepine receptors : Gabaergic regulation. In: Life Sciences. 1980 ; Vol. 26, No. 8. pp. 579-582.
@article{764d865a768943b798ee91639b0829d5,
title = "Soluble benzodiazepine receptors: Gabaergic regulation",
abstract = "Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.",
author = "Moshe Gavish and Snyder, {Solomon H}",
year = "1980",
month = "2",
day = "25",
doi = "10.1016/0024-3205(80)90231-3",
language = "English (US)",
volume = "26",
pages = "579--582",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Soluble benzodiazepine receptors

T2 - Gabaergic regulation

AU - Gavish, Moshe

AU - Snyder, Solomon H

PY - 1980/2/25

Y1 - 1980/2/25

N2 - Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

AB - Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

UR - http://www.scopus.com/inward/record.url?scp=0018848787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018848787&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(80)90231-3

DO - 10.1016/0024-3205(80)90231-3

M3 - Article

C2 - 7382735

AN - SCOPUS:0018848787

VL - 26

SP - 579

EP - 582

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 8

ER -