Soluble benzodiazepine receptors: Gabaergic regulation

Moshe Gavish, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

Original languageEnglish (US)
Pages (from-to)579-582
Number of pages4
JournalLife Sciences
Volume26
Issue number8
DOIs
StatePublished - Feb 25 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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