TY - JOUR
T1 - Solitary Fibrous Tumor of the Cerebellopontine Angle with Salivary Gland Heterotopia
T2 - A Unique Presentation
AU - Rodriguez, Fausto
AU - Scheithauer, Bernd W.
AU - Ockner, Daniel M.
AU - Giannini, Caterina
PY - 2004/1/1
Y1 - 2004/1/1
N2 - We report the unique association of a solitary fibrous tumor of the cerebellopontine angle with ectopic salivary gland tissue in a 53-year-old woman. The patient, diagnosed 21 years earlier with a right cerebellopontine angle fibrous meningioma, presented with a recurrent mass, which, upon surgical removal, showed features of a solitary fibrous tumor. Strong and diffuse immunoreactivity to CD34 and BCL-2 and a negative epithelial membrane antigen immunostain confirmed the diagnosis. Admixed with the spindle cell neoplasm, a bland glandular element composed of small glands and variably dilated tubules was noted. The vague tubuloacinar arrangement of the glands and the presence of acinar cells with a granular, periodic acid-Schiff-positive, basophilic cytoplasm, resembling serous type acini, were features of benign, although ectopic, salivary gland tissue. The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation.
AB - We report the unique association of a solitary fibrous tumor of the cerebellopontine angle with ectopic salivary gland tissue in a 53-year-old woman. The patient, diagnosed 21 years earlier with a right cerebellopontine angle fibrous meningioma, presented with a recurrent mass, which, upon surgical removal, showed features of a solitary fibrous tumor. Strong and diffuse immunoreactivity to CD34 and BCL-2 and a negative epithelial membrane antigen immunostain confirmed the diagnosis. Admixed with the spindle cell neoplasm, a bland glandular element composed of small glands and variably dilated tubules was noted. The vague tubuloacinar arrangement of the glands and the presence of acinar cells with a granular, periodic acid-Schiff-positive, basophilic cytoplasm, resembling serous type acini, were features of benign, although ectopic, salivary gland tissue. The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation.
KW - Cerebellopontine angle
KW - Ectopia
KW - Heterotopia
KW - Salivary gland
KW - Solitary fibrous tumor
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U2 - 10.1097/00000478-200401000-00017
DO - 10.1097/00000478-200401000-00017
M3 - Article
C2 - 14707876
AN - SCOPUS:0347419004
SN - 0147-5185
VL - 28
SP - 139
EP - 142
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 1
ER -