Solitary colorectal liver metastasis: Resection determines outcome

Thomas A. Aloia; Jean Nicolas Vauthey; Evelyne M. Loyer; Dario Ribero; Timothy M. Pawlik; Steven H. Wei; Steven A. Curley; Daria Zorzi; Eddie K. Abdalla; David M. Nagorney; Merril T. Dayton; Philip D. Schneider; Anton J. Bilchik; Kelly M. McMasters; William C. Chapman

doi:10.1001/archsurg.141.5.460

Solitary colorectal liver metastasis: Resection determines outcome

Thomas A. Aloia, Jean Nicolas Vauthey, Evelyne M. Loyer, Dario Ribero, Timothy M. Pawlik, Steven H. Wei, Steven A. Curley, Daria Zorzi, Eddie K. Abdalla, David M. Nagorney, Merril T. Dayton, Philip D. Schneider, Anton J. Bilchik, Kelly M. McMasters, William C. Chapman

Research output: Contribution to journal › Article › peer-review

357 Scopus citations

Abstract

Background: Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis. Hypothesis: Recurrence patterns after HR and RFA for solitary liver metastasis are similar. Design: Analysis of a prospective database at a tertiary care center with systematic review of follow-up imaging in all of the patients. Patients and Methods: Patients with solitary liver metastasis as the first site of metastasis treated for cure by HR or RFA were studied (patients received no prior liver-directed therapy). Prognostic factors, recurrence patterns, and survival rates were analyzed. Results: Of the 180 patients who were studied, 150 underwent HR and 30 underwent RFA. Radiofrequency ablation was used when resection would leave an inadequate liver remnant (20 patients) or comorbidity precluded safe HR (10 patients). Tumor size and treatment determined recurrence and survival. The local recurrence (LR) rate was markedly lower afterHR(5%) than after RFA (37%) (P

Original language	English (US)
Pages (from-to)	460-467
Number of pages	8
Journal	Archives of Surgery
Volume	141
Issue number	5
DOIs	https://doi.org/10.1001/archsurg.141.5.460
State	Published - May 2006
Externally published	Yes

ASJC Scopus subject areas

Surgery

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Aloia, T. A., Vauthey, J. N., Loyer, E. M., Ribero, D., Pawlik, T. M., Wei, S. H., Curley, S. A., Zorzi, D., Abdalla, E. K., Nagorney, D. M., Dayton, M. T., Schneider, P. D., Bilchik, A. J., McMasters, K. M., & Chapman, W. C. (2006). Solitary colorectal liver metastasis: Resection determines outcome. Archives of Surgery, 141(5), 460-467. https://doi.org/10.1001/archsurg.141.5.460

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title = "Solitary colorectal liver metastasis: Resection determines outcome",

abstract = "Background: Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis. Hypothesis: Recurrence patterns after HR and RFA for solitary liver metastasis are similar. Design: Analysis of a prospective database at a tertiary care center with systematic review of follow-up imaging in all of the patients. Patients and Methods: Patients with solitary liver metastasis as the first site of metastasis treated for cure by HR or RFA were studied (patients received no prior liver-directed therapy). Prognostic factors, recurrence patterns, and survival rates were analyzed. Results: Of the 180 patients who were studied, 150 underwent HR and 30 underwent RFA. Radiofrequency ablation was used when resection would leave an inadequate liver remnant (20 patients) or comorbidity precluded safe HR (10 patients). Tumor size and treatment determined recurrence and survival. The local recurrence (LR) rate was markedly lower afterHR(5%) than after RFA (37%) (P",

author = "Aloia, {Thomas A.} and Vauthey, {Jean Nicolas} and Loyer, {Evelyne M.} and Dario Ribero and Pawlik, {Timothy M.} and Wei, {Steven H.} and Curley, {Steven A.} and Daria Zorzi and Abdalla, {Eddie K.} and Nagorney, {David M.} and Dayton, {Merril T.} and Schneider, {Philip D.} and Bilchik, {Anton J.} and McMasters, {Kelly M.} and Chapman, {William C.}",

year = "2006",

month = may,

doi = "10.1001/archsurg.141.5.460",

language = "English (US)",

volume = "141",

pages = "460--467",

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T1 - Solitary colorectal liver metastasis

T2 - Resection determines outcome

AU - Aloia, Thomas A.

AU - Vauthey, Jean Nicolas

AU - Loyer, Evelyne M.

AU - Ribero, Dario

AU - Pawlik, Timothy M.

AU - Wei, Steven H.

AU - Curley, Steven A.

AU - Zorzi, Daria

AU - Abdalla, Eddie K.

AU - Nagorney, David M.

AU - Dayton, Merril T.

AU - Schneider, Philip D.

AU - Bilchik, Anton J.

AU - McMasters, Kelly M.

AU - Chapman, William C.

PY - 2006/5

Y1 - 2006/5

N2 - Background: Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis. Hypothesis: Recurrence patterns after HR and RFA for solitary liver metastasis are similar. Design: Analysis of a prospective database at a tertiary care center with systematic review of follow-up imaging in all of the patients. Patients and Methods: Patients with solitary liver metastasis as the first site of metastasis treated for cure by HR or RFA were studied (patients received no prior liver-directed therapy). Prognostic factors, recurrence patterns, and survival rates were analyzed. Results: Of the 180 patients who were studied, 150 underwent HR and 30 underwent RFA. Radiofrequency ablation was used when resection would leave an inadequate liver remnant (20 patients) or comorbidity precluded safe HR (10 patients). Tumor size and treatment determined recurrence and survival. The local recurrence (LR) rate was markedly lower afterHR(5%) than after RFA (37%) (P

AB - Background: Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis. Hypothesis: Recurrence patterns after HR and RFA for solitary liver metastasis are similar. Design: Analysis of a prospective database at a tertiary care center with systematic review of follow-up imaging in all of the patients. Patients and Methods: Patients with solitary liver metastasis as the first site of metastasis treated for cure by HR or RFA were studied (patients received no prior liver-directed therapy). Prognostic factors, recurrence patterns, and survival rates were analyzed. Results: Of the 180 patients who were studied, 150 underwent HR and 30 underwent RFA. Radiofrequency ablation was used when resection would leave an inadequate liver remnant (20 patients) or comorbidity precluded safe HR (10 patients). Tumor size and treatment determined recurrence and survival. The local recurrence (LR) rate was markedly lower afterHR(5%) than after RFA (37%) (P

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Solitary colorectal liver metastasis: Resection determines outcome

Abstract

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