Solitary colorectal liver metastasis: Resection determines outcome

Thomas A. Aloia, Jean Nicolas Vauthey, Evelyne M. Loyer, Dario Ribero, Timothy M. Pawlik, Steven H. Wei, Steven A. Curley, Daria Zorzi, Eddie K. Abdalla, David M. Nagorney, Merril T. Dayton, Philip D. Schneider, Anton J. Bilchik, Kelly M. McMasters, William C. Chapman

Research output: Contribution to journalArticle

Abstract

Background: Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis. Hypothesis: Recurrence patterns after HR and RFA for solitary liver metastasis are similar. Design: Analysis of a prospective database at a tertiary care center with systematic review of follow-up imaging in all of the patients. Patients and Methods: Patients with solitary liver metastasis as the first site of metastasis treated for cure by HR or RFA were studied (patients received no prior liver-directed therapy). Prognostic factors, recurrence patterns, and survival rates were analyzed. Results: Of the 180 patients who were studied, 150 underwent HR and 30 underwent RFA. Radiofrequency ablation was used when resection would leave an inadequate liver remnant (20 patients) or comorbidity precluded safe HR (10 patients). Tumor size and treatment determined recurrence and survival. The local recurrence (LR) rate was markedly lower afterHR(5%) than after RFA (37%) (P

Original languageEnglish (US)
Pages (from-to)460-467
Number of pages8
JournalArchives of Surgery
Volume141
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Aloia, T. A., Vauthey, J. N., Loyer, E. M., Ribero, D., Pawlik, T. M., Wei, S. H., Curley, S. A., Zorzi, D., Abdalla, E. K., Nagorney, D. M., Dayton, M. T., Schneider, P. D., Bilchik, A. J., McMasters, K. M., & Chapman, W. C. (2006). Solitary colorectal liver metastasis: Resection determines outcome. Archives of Surgery, 141(5), 460-467. https://doi.org/10.1001/archsurg.141.5.460