Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

Ling Wei, Yong Qian Wu, Douglas E. Wilkinson, Yi Chen, Raj Soni, Chad Scott, Douglas T. Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.

Original languageEnglish (US)
Pages (from-to)1429-1433
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number10
DOIs
StatePublished - May 20 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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