Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

Ling Wei; Yong Qian Wu; Douglas E. Wilkinson; Yi Chen; Raj Soni; Chad Scott; Douglas T. Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph Steiner; Gregory S. Hamilton

doi:10.1016/S0960-894X(02)00146-4

Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

Ling Wei, Yong Qian Wu, Douglas E. Wilkinson, Yi Chen, Raj Soni, Chad Scott, Douglas T. Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S. Hamilton

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.

Original language	English (US)
Pages (from-to)	1429-1433
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00146-4
State	Published - May 20 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(02)00146-4

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Wei, L., Wu, Y. Q., Wilkinson, D. E., Chen, Y., Soni, R., Scott, C., Ross, D. T., Guo, H., Howorth, P., Valentine, H., Liang, S., Spicer, D., Fuller, M., Steiner, J., & Hamilton, G. S. (2002). Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides. Bioorganic and Medicinal Chemistry Letters, 12(10), 1429-1433. https://doi.org/10.1016/S0960-894X(02)00146-4

Wei, L, Wu, YQ, Wilkinson, DE, Chen, Y, Soni, R, Scott, C, Ross, DT, Guo, H, Howorth, P, Valentine, H, Liang, S, Spicer, D, Fuller, M, Steiner, J & Hamilton, GS 2002, 'Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1429-1433. https://doi.org/10.1016/S0960-894X(02)00146-4

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title = "Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides",

abstract = "In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.",

author = "Ling Wei and Wu, {Yong Qian} and Wilkinson, {Douglas E.} and Yi Chen and Raj Soni and Chad Scott and Ross, {Douglas T.} and Hong Guo and Pamela Howorth and Heather Valentine and Shi Liang and Dawn Spicer and Mike Fuller and Joseph Steiner and Hamilton, {Gregory S.}",

year = "2002",

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doi = "10.1016/S0960-894X(02)00146-4",

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TY - JOUR

T1 - Solid-phase synthesis of FKBP12 inhibitors

T2 - N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

AU - Wei, Ling

AU - Wu, Yong Qian

AU - Wilkinson, Douglas E.

AU - Chen, Yi

AU - Soni, Raj

AU - Scott, Chad

AU - Ross, Douglas T.

AU - Guo, Hong

AU - Howorth, Pamela

AU - Valentine, Heather

AU - Liang, Shi

AU - Spicer, Dawn

AU - Fuller, Mike

AU - Steiner, Joseph

AU - Hamilton, Gregory S.

PY - 2002/5/20

Y1 - 2002/5/20

N2 - In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.

AB - In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.

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DO - 10.1016/S0960-894X(02)00146-4

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AN - SCOPUS:18344393965

SN - 0960-894X

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SP - 1429

EP - 1433

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

Abstract

ASJC Scopus subject areas

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