Solid-organ transplantation in older adults

Current status and future research

M. Abecassis, N. D. Bridges, C. J. Clancy, M. A. Dew, B. Eldadah, M. J. Englesbe, M. F. Flessner, J. C. Frank, J. Friedewald, J. Gill, C. Gries, J. B. Halter, E. L. Hartmann, W. R. Hazzard, F. M. Horne, J. Hosenpud, P. Jacobson, B. L. Kasiske, J. Lake, R. Loomba & 18 others P. N. Malani, T. M. Moore, A. Murray, M. H. Nguyen, N. R. Powe, P. P. Reese, H. Reynolds, M. D. Samaniego, K. E. Schmader, Dorry Segev, A. S. Shah, L. G. Singer, J. A. Sosa, Z. A. Stewart, J. C. Tan, W. W. Williams, D. W. Zaas, K. P. High

Research output: Contribution to journalArticle

Abstract

An increasing number of patients older than 65 years are referred for and have access to organ transplantation, and an increasing number of older adults are donating organs. Although short-term outcomes are similar in older versus younger transplant recipients, older donor or recipient age is associated with inferior long-term outcomes. However, age is often a proxy for other factors that might predict poor outcomes more strongly and better identify patients at risk for adverse events. Approaches to transplantation in older adults vary across programs, but despite recent gains in access and the increased use of marginal organs, older patients remain less likely than other groups to receive a transplant, and those who do are highly selected. Moreover, few studies have addressed geriatric issues in transplant patient selection or management, or the implications on health span and disability when patients age to late life with a transplanted organ. This paper summarizes a recent trans-disciplinary workshop held by ASP, in collaboration with NHLBI, NIA, NIAID, NIDDK and AGS, to address issues related to kidney, liver, lung, or heart transplantation in older adults and to propose a research agenda in these areas. This paper summarizes the proceedings of a recent trans-disciplinary workshop on transplantation in the elderly, presenting the current status and issues of transplantation in older adults and outlining important areas for research. See editorial by Goldstein on page 2569.

Original languageEnglish (US)
Pages (from-to)2608-2622
Number of pages15
JournalAmerican Journal of Transplantation
Volume12
Issue number10
DOIs
StatePublished - Oct 2012
Externally publishedYes

Fingerprint

Organ Transplantation
Transplantation
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
National Institute of Allergy and Infectious Diseases (U.S.)
National Heart, Lung, and Blood Institute (U.S.)
Transplants
Education
Proxy
Research
Geriatrics
Liver Transplantation
Patient Selection
Tissue Donors
Kidney
Lung
Health

Keywords

  • Aging
  • elderly
  • heart
  • kidney
  • liver
  • lung
  • transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Abecassis, M., Bridges, N. D., Clancy, C. J., Dew, M. A., Eldadah, B., Englesbe, M. J., ... High, K. P. (2012). Solid-organ transplantation in older adults: Current status and future research. American Journal of Transplantation, 12(10), 2608-2622. https://doi.org/10.1111/j.1600-6143.2012.04245.x

Solid-organ transplantation in older adults : Current status and future research. / Abecassis, M.; Bridges, N. D.; Clancy, C. J.; Dew, M. A.; Eldadah, B.; Englesbe, M. J.; Flessner, M. F.; Frank, J. C.; Friedewald, J.; Gill, J.; Gries, C.; Halter, J. B.; Hartmann, E. L.; Hazzard, W. R.; Horne, F. M.; Hosenpud, J.; Jacobson, P.; Kasiske, B. L.; Lake, J.; Loomba, R.; Malani, P. N.; Moore, T. M.; Murray, A.; Nguyen, M. H.; Powe, N. R.; Reese, P. P.; Reynolds, H.; Samaniego, M. D.; Schmader, K. E.; Segev, Dorry; Shah, A. S.; Singer, L. G.; Sosa, J. A.; Stewart, Z. A.; Tan, J. C.; Williams, W. W.; Zaas, D. W.; High, K. P.

In: American Journal of Transplantation, Vol. 12, No. 10, 10.2012, p. 2608-2622.

Research output: Contribution to journalArticle

Abecassis, M, Bridges, ND, Clancy, CJ, Dew, MA, Eldadah, B, Englesbe, MJ, Flessner, MF, Frank, JC, Friedewald, J, Gill, J, Gries, C, Halter, JB, Hartmann, EL, Hazzard, WR, Horne, FM, Hosenpud, J, Jacobson, P, Kasiske, BL, Lake, J, Loomba, R, Malani, PN, Moore, TM, Murray, A, Nguyen, MH, Powe, NR, Reese, PP, Reynolds, H, Samaniego, MD, Schmader, KE, Segev, D, Shah, AS, Singer, LG, Sosa, JA, Stewart, ZA, Tan, JC, Williams, WW, Zaas, DW & High, KP 2012, 'Solid-organ transplantation in older adults: Current status and future research', American Journal of Transplantation, vol. 12, no. 10, pp. 2608-2622. https://doi.org/10.1111/j.1600-6143.2012.04245.x
Abecassis, M. ; Bridges, N. D. ; Clancy, C. J. ; Dew, M. A. ; Eldadah, B. ; Englesbe, M. J. ; Flessner, M. F. ; Frank, J. C. ; Friedewald, J. ; Gill, J. ; Gries, C. ; Halter, J. B. ; Hartmann, E. L. ; Hazzard, W. R. ; Horne, F. M. ; Hosenpud, J. ; Jacobson, P. ; Kasiske, B. L. ; Lake, J. ; Loomba, R. ; Malani, P. N. ; Moore, T. M. ; Murray, A. ; Nguyen, M. H. ; Powe, N. R. ; Reese, P. P. ; Reynolds, H. ; Samaniego, M. D. ; Schmader, K. E. ; Segev, Dorry ; Shah, A. S. ; Singer, L. G. ; Sosa, J. A. ; Stewart, Z. A. ; Tan, J. C. ; Williams, W. W. ; Zaas, D. W. ; High, K. P. / Solid-organ transplantation in older adults : Current status and future research. In: American Journal of Transplantation. 2012 ; Vol. 12, No. 10. pp. 2608-2622.
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