Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients

Giacomo Novara, Robert S. Svatek, Pierre I. Karakiewicz, Eila Skinner, Vincenzo Ficarra, Yves Fradet, Yair Lotan, Hendrik Isbarn, Umberto Capitanio, Patrick J. Bastian, Wassim Kassouf, Hans Martin Fritsche, Jonathan I. Izawa, Derya Tilki, Colin P. Dinney, Seth P. Lerner, Mark Schoenberg, Bjoern G. Volkmer, Arthur I. Sagalowsky, Shahrokh F. Shariat

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

Original languageEnglish (US)
Pages (from-to)2165-2170
Number of pages6
JournalJournal of Urology
Volume183
Issue number6
DOIs
StatePublished - Jun 2010

Fingerprint

Cystectomy
Multicenter Studies
Lymph Node Excision
Canada
Neoplasms
Urinary Bladder
Lymph Nodes
Margins of Excision
Neoplasm Metastasis
Carcinoma
Drug Therapy

Keywords

  • carcinoma
  • cystectomy
  • prognosis
  • survival
  • transitional cell
  • urinary bladder neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy : A Multicenter Study of More Than 4,400 Patients. / Novara, Giacomo; Svatek, Robert S.; Karakiewicz, Pierre I.; Skinner, Eila; Ficarra, Vincenzo; Fradet, Yves; Lotan, Yair; Isbarn, Hendrik; Capitanio, Umberto; Bastian, Patrick J.; Kassouf, Wassim; Fritsche, Hans Martin; Izawa, Jonathan I.; Tilki, Derya; Dinney, Colin P.; Lerner, Seth P.; Schoenberg, Mark; Volkmer, Bjoern G.; Sagalowsky, Arthur I.; Shariat, Shahrokh F.

In: Journal of Urology, Vol. 183, No. 6, 06.2010, p. 2165-2170.

Research output: Contribution to journalArticle

Novara, G, Svatek, RS, Karakiewicz, PI, Skinner, E, Ficarra, V, Fradet, Y, Lotan, Y, Isbarn, H, Capitanio, U, Bastian, PJ, Kassouf, W, Fritsche, HM, Izawa, JI, Tilki, D, Dinney, CP, Lerner, SP, Schoenberg, M, Volkmer, BG, Sagalowsky, AI & Shariat, SF 2010, 'Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients', Journal of Urology, vol. 183, no. 6, pp. 2165-2170. https://doi.org/10.1016/j.juro.2010.02.021
Novara, Giacomo ; Svatek, Robert S. ; Karakiewicz, Pierre I. ; Skinner, Eila ; Ficarra, Vincenzo ; Fradet, Yves ; Lotan, Yair ; Isbarn, Hendrik ; Capitanio, Umberto ; Bastian, Patrick J. ; Kassouf, Wassim ; Fritsche, Hans Martin ; Izawa, Jonathan I. ; Tilki, Derya ; Dinney, Colin P. ; Lerner, Seth P. ; Schoenberg, Mark ; Volkmer, Bjoern G. ; Sagalowsky, Arthur I. ; Shariat, Shahrokh F. / Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy : A Multicenter Study of More Than 4,400 Patients. In: Journal of Urology. 2010 ; Vol. 183, No. 6. pp. 2165-2170.
@article{b16a1c209f5a4794934e69d35dc435ef,
title = "Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of More Than 4,400 Patients",
abstract = "Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3{\%}). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p",
keywords = "carcinoma, cystectomy, prognosis, survival, transitional cell, urinary bladder neoplasms",
author = "Giacomo Novara and Svatek, {Robert S.} and Karakiewicz, {Pierre I.} and Eila Skinner and Vincenzo Ficarra and Yves Fradet and Yair Lotan and Hendrik Isbarn and Umberto Capitanio and Bastian, {Patrick J.} and Wassim Kassouf and Fritsche, {Hans Martin} and Izawa, {Jonathan I.} and Derya Tilki and Dinney, {Colin P.} and Lerner, {Seth P.} and Mark Schoenberg and Volkmer, {Bjoern G.} and Sagalowsky, {Arthur I.} and Shariat, {Shahrokh F.}",
year = "2010",
month = "6",
doi = "10.1016/j.juro.2010.02.021",
language = "English (US)",
volume = "183",
pages = "2165--2170",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy

T2 - A Multicenter Study of More Than 4,400 Patients

AU - Novara, Giacomo

AU - Svatek, Robert S.

AU - Karakiewicz, Pierre I.

AU - Skinner, Eila

AU - Ficarra, Vincenzo

AU - Fradet, Yves

AU - Lotan, Yair

AU - Isbarn, Hendrik

AU - Capitanio, Umberto

AU - Bastian, Patrick J.

AU - Kassouf, Wassim

AU - Fritsche, Hans Martin

AU - Izawa, Jonathan I.

AU - Tilki, Derya

AU - Dinney, Colin P.

AU - Lerner, Seth P.

AU - Schoenberg, Mark

AU - Volkmer, Bjoern G.

AU - Sagalowsky, Arthur I.

AU - Shariat, Shahrokh F.

PY - 2010/6

Y1 - 2010/6

N2 - Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

AB - Purpose: We evaluated the association of soft tissue surgical margins with characteristics and outcomes of patients treated with radical cystectomy for urothelial carcinoma of the bladder. Materials and Methods: We retrospectively collected the data of 4,410 patients treated with radical cystectomy and pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in the United States, Canada and Europe. A positive soft tissue surgical margin was defined as presence of tumor at inked areas of soft tissue on the radical cystectomy specimen. Results: Positive soft tissue surgical margins were identified in 278 patients (6.3%). On univariate analysis positive soft tissue surgical margin was significantly associated with advanced pT stage, higher tumor grade, lymphovascular invasion and lymph node metastasis (p

KW - carcinoma

KW - cystectomy

KW - prognosis

KW - survival

KW - transitional cell

KW - urinary bladder neoplasms

UR - http://www.scopus.com/inward/record.url?scp=77951878964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951878964&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2010.02.021

DO - 10.1016/j.juro.2010.02.021

M3 - Article

C2 - 20399473

AN - SCOPUS:77951878964

VL - 183

SP - 2165

EP - 2170

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -