Soft drink and juice consumption and risk of pancreatic cancer: The singapore chinese health study

Noel Mueller, Andrew Odegaard, Kristin Anderson, Jian Min Yuan, Myron Gross, Woon Puay Koh, Mark A. Pereira

Research output: Contribution to journalArticle

Abstract

Background: Sugar-sweetened carbonated beverages (called soft drinks) and juices, which have a high glycemic load relative to other foods and beverages, have been hypothesized as pancreatic cancer risk factors. However, data thus far are scarce, especially from non-European descent populations. We investigated whether higher consumption of soft drinks and juice increases the risk of pancreatic cancer in Chinese men and women. Methods: A prospective cohort analysis was done to examine the association between soft drink and juice consumption and the risk of pancreatic cancer in 60,524 participants of the Singapore Chinese Health Study with up to 14 years of follow-up. Information on consumption of soft drinks, juice, and other dietary items, as well as lifestyle and environmental exposures, was collected through in-person interviews at recruitment. Pancreatic cancer cases and deaths were ascertained by record linkage of the cohort database with records of population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths. Results: The first 14 years for the cohort resulted in cumulative 648,387 person-years and 140 incident pancreatic cancer cases. Individuals consuming ≥2 soft drinks/wk experienced a statistically significant increased risk of pancreatic cancer (hazard ratio, 1.87; 95% confidence interval, 1.10-3.15) compared with individuals who did not consume soft drinks after adjustment for potential confounders. There was no statistically significant association between juice consumption and risk of pancreatic cancer. Conclusion: Regular consumption of soft drinks may play an independent role in the development of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

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Carbonated Beverages
Singapore
Pancreatic Neoplasms
Health
Registries
Food and Beverages
Environmental Exposure
Population
Life Style
Cohort Studies
Parturition
Databases
Confidence Intervals
Interviews

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Soft drink and juice consumption and risk of pancreatic cancer : The singapore chinese health study. / Mueller, Noel; Odegaard, Andrew; Anderson, Kristin; Yuan, Jian Min; Gross, Myron; Koh, Woon Puay; Pereira, Mark A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 19, No. 2, 02.2010, p. 447-455.

Research output: Contribution to journalArticle

Mueller, Noel ; Odegaard, Andrew ; Anderson, Kristin ; Yuan, Jian Min ; Gross, Myron ; Koh, Woon Puay ; Pereira, Mark A. / Soft drink and juice consumption and risk of pancreatic cancer : The singapore chinese health study. In: Cancer Epidemiology Biomarkers and Prevention. 2010 ; Vol. 19, No. 2. pp. 447-455.
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abstract = "Background: Sugar-sweetened carbonated beverages (called soft drinks) and juices, which have a high glycemic load relative to other foods and beverages, have been hypothesized as pancreatic cancer risk factors. However, data thus far are scarce, especially from non-European descent populations. We investigated whether higher consumption of soft drinks and juice increases the risk of pancreatic cancer in Chinese men and women. Methods: A prospective cohort analysis was done to examine the association between soft drink and juice consumption and the risk of pancreatic cancer in 60,524 participants of the Singapore Chinese Health Study with up to 14 years of follow-up. Information on consumption of soft drinks, juice, and other dietary items, as well as lifestyle and environmental exposures, was collected through in-person interviews at recruitment. Pancreatic cancer cases and deaths were ascertained by record linkage of the cohort database with records of population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths. Results: The first 14 years for the cohort resulted in cumulative 648,387 person-years and 140 incident pancreatic cancer cases. Individuals consuming ≥2 soft drinks/wk experienced a statistically significant increased risk of pancreatic cancer (hazard ratio, 1.87; 95{\%} confidence interval, 1.10-3.15) compared with individuals who did not consume soft drinks after adjustment for potential confounders. There was no statistically significant association between juice consumption and risk of pancreatic cancer. Conclusion: Regular consumption of soft drinks may play an independent role in the development of pancreatic cancer.",
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