Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory

Frank Riemer, Bhavana S. Solanky, Christian Stehning, Matthew Clemence, Claudia A M Wheeler-Kingshott, Xavier Golay

Research output: Contribution to journalArticle

Abstract

Object: Sodium magnetic resonance imaging (23Na-MRI) of the brain has shown changes in 23Na signal as a hallmark of various neurological diseases such as stroke, Alzheimer's disease, Multiple Sclerosis and Huntington's disease. To improve scan times and image quality, we have implemented the 3D-Cones (CN) sequence for in vivo 23Na brain MRI. Materials and methods: Using signal-to-noise (SNR) as a measurement of sequence performance, CN is compared against more established 3D-radial k-space sampling schemes featuring cylindrical stack-of-stars (SOS) and 3D-spokes kooshball (KB) trajectories, on five healthy volunteers in a clinical setting. Resolution was evaluated by simulating the point-spread-functions (PSFs) and experimental measures on a phantom. Results: All sequences were shown to have a similar SNR arbitrary units (AU) of 6-6.5 in brain white matter, 7-9 in gray matter and 17-18 AU in cerebrospinal fluid. SNR between white and gray matter were significantly different for KB and CN (p = 0.046 and 23Na-MRI in the brain.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalMagma (New York, N.Y.)
Volume27
Issue number1
DOIs
StatePublished - Feb 2014
Externally publishedYes

Fingerprint

Sodium
Brain
Huntington Disease
Multiple Sclerosis
Cerebrospinal Fluid
Noise
Healthy Volunteers
Alzheimer Disease
Stroke
Magnetic Resonance Imaging
White Matter
Gray Matter

Keywords

  • Na
  • Cones
  • Non-Cartesian
  • Sodium
  • UTE

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Riemer, F., Solanky, B. S., Stehning, C., Clemence, M., Wheeler-Kingshott, C. A. M., & Golay, X. (2014). Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory. Magma (New York, N.Y.), 27(1), 35-46. https://doi.org/10.1007/s10334-013-0395-2

Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory. / Riemer, Frank; Solanky, Bhavana S.; Stehning, Christian; Clemence, Matthew; Wheeler-Kingshott, Claudia A M; Golay, Xavier.

In: Magma (New York, N.Y.), Vol. 27, No. 1, 02.2014, p. 35-46.

Research output: Contribution to journalArticle

Riemer, F, Solanky, BS, Stehning, C, Clemence, M, Wheeler-Kingshott, CAM & Golay, X 2014, 'Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory', Magma (New York, N.Y.), vol. 27, no. 1, pp. 35-46. https://doi.org/10.1007/s10334-013-0395-2
Riemer F, Solanky BS, Stehning C, Clemence M, Wheeler-Kingshott CAM, Golay X. Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory. Magma (New York, N.Y.). 2014 Feb;27(1):35-46. https://doi.org/10.1007/s10334-013-0395-2
Riemer, Frank ; Solanky, Bhavana S. ; Stehning, Christian ; Clemence, Matthew ; Wheeler-Kingshott, Claudia A M ; Golay, Xavier. / Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory. In: Magma (New York, N.Y.). 2014 ; Vol. 27, No. 1. pp. 35-46.
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