Sodium lactate increases sympathovagal ratios in normal control subjects: Spectral analysis of heart rate, blood pressure, and respiration

Vikram K. Yeragani; K. Srinivasan; R. Pohl; R. Berger; R. Balon; R. Berchou

doi:10.1016/0165-1781(94)90068-X

Sodium lactate increases sympathovagal ratios in normal control subjects: Spectral analysis of heart rate, blood pressure, and respiration

Vikram K. Yeragani, K. Srinivasan, R. Pohl, R. Berger, R. Balon, R. Berchou

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.

Original language	English (US)
Pages (from-to)	97-114
Number of pages	18
Journal	Psychiatry research
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(94)90068-X
State	Published - Oct 1994

Keywords

Panic disorder
blood pressure
heart rate
spectral analysis

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(94)90068-X

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abstract = "We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.",

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T2 - Spectral analysis of heart rate, blood pressure, and respiration

AU - Yeragani, Vikram K.

AU - Srinivasan, K.

AU - Pohl, R.

AU - Berger, R.

AU - Balon, R.

AU - Berchou, R.

PY - 1994/10

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N2 - We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.

AB - We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.

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KW - blood pressure

KW - heart rate

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Sodium lactate increases sympathovagal ratios in normal control subjects: Spectral analysis of heart rate, blood pressure, and respiration

Abstract

Keywords

ASJC Scopus subject areas

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