Sodium excretion and the risk of cardiovascular disease in patients with chronic kidney disease

Katherine T. Mills, Jing Chen, Wei Yang, Lawrence Appel, John W. Kusek, Arnold Alper, Patrice Delafontaine, Martin G. Keane, Emile Mohler, Akinlolu Ojo, Mahboob Rahman, Ana C. Ricardo, Elsayed Z. Soliman, Susan Steigerwalt, Raymond Townsend, Jiang He

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Patients with chronic kidney disease (CKD) are at an increased risk of cardiovascular disease (CVD) compared with the general population. Prior studies have produced contradictory results on the association of dietary sodium intake with risk of CVD, and this relationship has not been investigated in patients with CKD. OBJECTIVE: To evaluate the association between urinary sodium excretion and clinical CVD events among patients with CKD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of patients with CKD from 7 locations in the United States enrolled in the Chronic Renal Insufficiency Cohort Study and followed up from May 2003 to March 2013. EXPOSURES: The cumulative mean of urinary sodium excretion from three 24-hour urinary measurements and calibrated to sex-specific mean 24-hour urinary creatinine excretion. MAIN OUTCOMES AND MEASURES: A composite of CVD events defined as congestive heart failure, stroke, or myocardial infarction. Events were reported every 6 months and confirmed by medical record adjudication. RESULTS: Among3757 participants (mean age, 58 years; 45% women), 804 composite CVD events (575 heart failure, 305 myocardial infarction, and 148 stroke) occurred during a median 6.8 years of follow-up. From lowest (

Original languageEnglish (US)
Pages (from-to)2200-2210
Number of pages11
JournalJournal of the American Medical Association
Volume315
Issue number20
DOIs
StatePublished - May 24 2016

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Sodium excretion and the risk of cardiovascular disease in patients with chronic kidney disease'. Together they form a unique fingerprint.

  • Cite this

    Mills, K. T., Chen, J., Yang, W., Appel, L., Kusek, J. W., Alper, A., Delafontaine, P., Keane, M. G., Mohler, E., Ojo, A., Rahman, M., Ricardo, A. C., Soliman, E. Z., Steigerwalt, S., Townsend, R., & He, J. (2016). Sodium excretion and the risk of cardiovascular disease in patients with chronic kidney disease. Journal of the American Medical Association, 315(20), 2200-2210. https://doi.org/10.1001/jama.2016.4447