Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population

Latife Pereira, Roxana Zamudio, Giordano Soares-Souza, Phabiola Herrera, Lilia Cabrera, Catherine C. Hooper, Jaime Cok, Juan M. Combe, Gloria Vargas, William A. Prado, Silvana Schneider, Fernanda Kehdy, Maira R. Rodrigues, Stephen J. Chanock, Douglas E. Berg, Robert H Gilman, Eduardo Tarazona-Santos

Research output: Contribution to journalArticle

Abstract

Gastric cancer is one of the most lethal types of cancer and its incidence varies worldwide, with the Andean region of South America showing high incidence rates. We evaluated the genetic structure of the population from Lima (Peru) and performed a case-control genetic association study to test the contribution of African, European, or Native American ancestry to risk for gastric cancer, controlling for the effect of non-genetic factors. A wide set of socioeconomic, dietary, and clinic information was collected for each participant in the study and ancestry was estimated based on 103 ancestry informative markers. Although the urban population from Lima is usually considered as mestizo (i.e., admixed from Africans, Europeans, and Native Americans), we observed a high fraction of Native American ancestry (78.4% for the cases and 74.6% for the controls) and a very low African ancestry (

Original languageEnglish (US)
Article numbere41200
JournalPLoS One
Volume7
Issue number8
DOIs
StatePublished - Aug 3 2012

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stomach neoplasms
North American Indians
American Indians
Stomach Neoplasms
socioeconomics
ancestry
African Americans
Population
Peru
Urban Population
South America
Genetic Structures
Incidence
Genetic Association Studies
incidence
Andes region
urban population
population structure
Neoplasms
neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Pereira, L., Zamudio, R., Soares-Souza, G., Herrera, P., Cabrera, L., Hooper, C. C., ... Tarazona-Santos, E. (2012). Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population. PLoS One, 7(8), [e41200]. https://doi.org/10.1371/journal.pone.0041200

Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population. / Pereira, Latife; Zamudio, Roxana; Soares-Souza, Giordano; Herrera, Phabiola; Cabrera, Lilia; Hooper, Catherine C.; Cok, Jaime; Combe, Juan M.; Vargas, Gloria; Prado, William A.; Schneider, Silvana; Kehdy, Fernanda; Rodrigues, Maira R.; Chanock, Stephen J.; Berg, Douglas E.; Gilman, Robert H; Tarazona-Santos, Eduardo.

In: PLoS One, Vol. 7, No. 8, e41200, 03.08.2012.

Research output: Contribution to journalArticle

Pereira, L, Zamudio, R, Soares-Souza, G, Herrera, P, Cabrera, L, Hooper, CC, Cok, J, Combe, JM, Vargas, G, Prado, WA, Schneider, S, Kehdy, F, Rodrigues, MR, Chanock, SJ, Berg, DE, Gilman, RH & Tarazona-Santos, E 2012, 'Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population', PLoS One, vol. 7, no. 8, e41200. https://doi.org/10.1371/journal.pone.0041200
Pereira, Latife ; Zamudio, Roxana ; Soares-Souza, Giordano ; Herrera, Phabiola ; Cabrera, Lilia ; Hooper, Catherine C. ; Cok, Jaime ; Combe, Juan M. ; Vargas, Gloria ; Prado, William A. ; Schneider, Silvana ; Kehdy, Fernanda ; Rodrigues, Maira R. ; Chanock, Stephen J. ; Berg, Douglas E. ; Gilman, Robert H ; Tarazona-Santos, Eduardo. / Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population. In: PLoS One. 2012 ; Vol. 7, No. 8.
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