TY - JOUR
T1 - Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study
AU - Petrovic, Dusan
AU - Pivin, Edward
AU - Ponte, Belen
AU - Dhayat, Nasser
AU - Pruijm, Menno
AU - Ehret, Georg
AU - Ackermann, Daniel
AU - Guessous, Idris
AU - Younes, Sandrine Estoppey
AU - Pechère-Bertschi, Antoinette
AU - Vogt, Bruno
AU - Mohaupt, Markus
AU - Martin, Pierre Yves
AU - Paccaud, Fred
AU - Burnier, Michel
AU - Bochud, Murielle
AU - Stringhini, Silvia
N1 - Funding Information:
The authors would like to express their gratitude to the participants of the SKIPOGH study and to the investigators who have contributed to the recruitment, in particular Marie-Odile Levy, Guler Gök-Sogüt, Ulla Schüpbach, and Dominique Siminski.
Funding Information:
Silvia Stringhini is supported by the Swiss national science foundation (Ambizione Grant no. PZ00P3_147998). This work is supported by the European commission and the Swiss state secretariat for education, research and innovation—SERI (Horizon 2020 grant no. 633666). The SKIPOGH study is supported by a grant from the Swiss national science foundation ( FN 33CM30-124087 ). Some of the results of this paper were obtained by using the program package S.A.G.E., which was supported by a U.S. Public health service resource grant ( RR03655 ) from the National center for research resources . The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of data; and preparation, review or approval of the manuscript.
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48 ± 16 years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR = 3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR = 0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR = 3.54, 95%CI [1.69;7.4]/OR = 1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance.
AB - Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48 ± 16 years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR = 3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR = 0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR = 3.54, 95%CI [1.69;7.4]/OR = 1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance.
KW - Allostatic load
KW - Heritability
KW - Physiological dysregulation
KW - Population-based
KW - Socioeconomic status
UR - http://www.scopus.com/inward/record.url?scp=84962621700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962621700&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2016.02.003
DO - 10.1016/j.psyneuen.2016.02.003
M3 - Article
C2 - 26881833
AN - SCOPUS:84962621700
VL - 67
SP - 76
EP - 85
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -