Social stress: From rodents to primates

Kellie L.K. Tamashiro, Mary M.N. Nguyen, Randall R. Sakai

Research output: Contribution to journalArticlepeer-review

Abstract

Social stress is associated with development of many psychological and physiological disturbances in humans. Animal models are needed to determine the etiology of these diseases and to develop rational clinical therapies to treat those afflicted. Rodent and non-human primate models of social stress have been developed to address these needs and contribute in complementary ways to the understanding of social stress. In this review, we provide an overview of common rodent and non-human primate models of social stress used in the laboratory with a focus on social hierarchy models. The implications of the current findings on understanding of the development of stress-related disease will also be discussed.

Original languageEnglish (US)
Pages (from-to)27-40
Number of pages14
JournalFrontiers in Neuroendocrinology
Volume26
Issue number1
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Animal model
  • Dominance
  • Mouse
  • Non-human primate
  • Rat
  • Social stress
  • Subordination

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

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