TY - JOUR
T1 - Social cognition in Alzheimer's disease
T2 - A separate construct contributing to dependence
AU - Cosentino, Stephanie
AU - Zahodne, Laura B.
AU - Brandt, Jason
AU - Blacker, Deborah
AU - Albert, Marilyn
AU - Dubois, Bruno
AU - Stern, Yaakov
N1 - Funding Information:
The Predictors study is supported by a National Institute on Aging (NIA) grant ( R01 AG007370 ) to Dr. Stern. Dr. Cosentino is supported by a Paul B. Beeson Career Development Award in Aging ( K23 AG032899 ). Dr. Zahodne is supported by an NIA grant ( T32 AG000261 ). This publication was also supported by the National Center for Advancing Translational Sciences , National Institutes of Health (through grant no. UL1 TR000040 ), formerly the National Center for Research Resources (grant no. UL1 RR024156 ).
Publisher Copyright:
© 2014 The Alzheimer's Association. All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer's disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition measured with six items from the Blessed Dementia Rating Scale, general cognition, and dependence in 517 participants with probable AD. Participants were monitored every 6 months for 5.5 years. Results from multivariate latent growth curve models adjusted for sex, age, education, depression, and recruitment site revealed that social cognition and general cognition were unrelated cross-sectionally and throughout time. However, baseline levels of each were related independently to dependence, and change values of each were related independently to change in dependence. These findings highlight the separability of social and general cognition in AD. Results underscore the relevance of considering social cognition when modeling disease and estimating clinical outcomes related to patient disability.
AB - The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer's disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition measured with six items from the Blessed Dementia Rating Scale, general cognition, and dependence in 517 participants with probable AD. Participants were monitored every 6 months for 5.5 years. Results from multivariate latent growth curve models adjusted for sex, age, education, depression, and recruitment site revealed that social cognition and general cognition were unrelated cross-sectionally and throughout time. However, baseline levels of each were related independently to dependence, and change values of each were related independently to change in dependence. These findings highlight the separability of social and general cognition in AD. Results underscore the relevance of considering social cognition when modeling disease and estimating clinical outcomes related to patient disability.
KW - Alzheimer's disease
KW - Cognition
KW - Dependence
KW - Social cognition
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U2 - 10.1016/j.jalz.2013.12.021
DO - 10.1016/j.jalz.2013.12.021
M3 - Article
C2 - 24656839
AN - SCOPUS:84927174005
SN - 1552-5260
VL - 10
SP - 818
EP - 826
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 6
ER -