SNP43 of CAPN10 and the risk of type 2 diabetes in African-Americans: The atherosclerosis risk in communities study

Michael J. Garant, W. H. Linda Kao, Frederick Brancati, Josef Coresh, Tejal M. Rami, Craig L. Hanis, Eric Boerwinkle, Alan R. Shuldiner

Research output: Contribution to journalArticle

Abstract

Recently, an A-to-G variant in intron 3 (SNP43) of the calcium-activated neutral protease 10 gene (CAPN10) was identified as a possible type 2 diabetes susceptibility gene through positional cloning in Mexican-Americans. We conducted cross-sectional and prospective studies to evaluate the relation between SNP43 and type 2 diabetes and related traits in middle-aged African-American participants of the Atherosclerosis Risk in Communities Study, a population-based longitudinal study. At baseline, 269 prevalent diabetes cases and 1,159 nondiabetic control subjects were studied. Those with the G/G genotype were more likely to have diabetes than those with the A/G or A/A genotype (odds ratio [OR] 1.41, 95% CI 1.00-1.99, P = 0.05). In the prospective study, 166 of the control subjects developed incident diabetes over 9 years of follow-up. The incidence of diabetes for individuals with the G/G genotype did not differ significantly from those with at least one copy of the A allele (23.3 vs. 19.5 per 1,000 person years, P = 0.29). Pooling prevalent and incident diabetic cases together, individuals with the G/G genotype were -40% more likely to have diabetes than those without (OR 1.38, 95% CI 1.04-1.83, P = 0.03). Because of the high frequency of the G allele (0.88), -25% of the susceptibility to type 2 diabetes in African-Americans may be attributed to the G/G genotype at SNP43 of CAPN10, although most of the subjects with the G/G genotype did not develop diabetes over the 9 years of follow-up. We conclude from this large prospective study that the G allele of SNP43 of CAPN10 or another allele or gene that is in linkage disequilibrium with it increases susceptibility to type 2 diabetes in African-Americans.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalDiabetes
Volume51
Issue number1
StatePublished - 2002

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African Americans
Type 2 Diabetes Mellitus
Atherosclerosis
Genotype
Alleles
Prospective Studies
Odds Ratio
Genes
Calpain
Linkage Disequilibrium
Gene Frequency
Introns
Longitudinal Studies
Organism Cloning
Cross-Sectional Studies
Incidence
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Garant, M. J., Linda Kao, W. H., Brancati, F., Coresh, J., Rami, T. M., Hanis, C. L., ... Shuldiner, A. R. (2002). SNP43 of CAPN10 and the risk of type 2 diabetes in African-Americans: The atherosclerosis risk in communities study. Diabetes, 51(1), 231-237.

SNP43 of CAPN10 and the risk of type 2 diabetes in African-Americans : The atherosclerosis risk in communities study. / Garant, Michael J.; Linda Kao, W. H.; Brancati, Frederick; Coresh, Josef; Rami, Tejal M.; Hanis, Craig L.; Boerwinkle, Eric; Shuldiner, Alan R.

In: Diabetes, Vol. 51, No. 1, 2002, p. 231-237.

Research output: Contribution to journalArticle

Garant, MJ, Linda Kao, WH, Brancati, F, Coresh, J, Rami, TM, Hanis, CL, Boerwinkle, E & Shuldiner, AR 2002, 'SNP43 of CAPN10 and the risk of type 2 diabetes in African-Americans: The atherosclerosis risk in communities study', Diabetes, vol. 51, no. 1, pp. 231-237.
Garant, Michael J. ; Linda Kao, W. H. ; Brancati, Frederick ; Coresh, Josef ; Rami, Tejal M. ; Hanis, Craig L. ; Boerwinkle, Eric ; Shuldiner, Alan R. / SNP43 of CAPN10 and the risk of type 2 diabetes in African-Americans : The atherosclerosis risk in communities study. In: Diabetes. 2002 ; Vol. 51, No. 1. pp. 231-237.
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