SnapShot: Cartography of Intramembrane Proteolysis

Siniša Urban

Research output: Contribution to journalShort surveypeer-review

Abstract

Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.

Original languageEnglish (US)
Pages (from-to)1898-1898.e1
JournalCell
Volume167
Issue number7
DOIs
StatePublished - Dec 15 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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