SnapShot: Cartography of Intramembrane Proteolysis

Siniša Urban

doi:10.1016/j.cell.2016.11.043

SnapShot: Cartography of Intramembrane Proteolysis

Siniša Urban

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.

Original language	English (US)
Pages (from-to)	1898-1898.e1
Journal	Cell
Volume	167
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2016.11.043
State	Published - Dec 15 2016

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.",

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