Abstract
Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normal in the early phase of renovascular hypertension. These results offer strong evidence that the renin- angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.
Original language | English (US) |
---|---|
Pages (from-to) | 321-324 |
Number of pages | 4 |
Journal | Anesthesiology |
Volume | 126 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2017 |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine