Smoothened goes molecular: New pieces in the hedgehog signaling puzzle

Jacqueline M. McCabe, Daniel J. Leahy

Research output: Contribution to journalArticle

Abstract

A general aim of studies of signal transduction is to identify mediators of specific signals, order them into pathways, and understand the nature of interactions between individual components and how these interactions alter pathway behavior. Despite years of intensive study and its central importance to animal development and human health, our understanding of the Hedgehog (Hh) signaling pathway remains riddled with gaps, question marks, assumptions, and poorly understood connections. In particular, understanding how interactions between Hh and Patched (Ptc), a 12-pass integral membrane protein, lead to modulation of the function of Smoothened (Smo), a 7-pass integral membrane protein, has defied standard biochemical characterization. Recent structural and biochemical characterizations of Smoothened domains have begun to unlock this riddle, however, and lay the groundwork for improved cancer therapies.

Original languageEnglish (US)
Pages (from-to)3500-3507
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number6
DOIs
StatePublished - Feb 6 2015

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Hedgehogs
Membrane Proteins
Signal transduction
Human Development
Signal Transduction
Animals
Modulation
Health
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Smoothened goes molecular : New pieces in the hedgehog signaling puzzle. / McCabe, Jacqueline M.; Leahy, Daniel J.

In: Journal of Biological Chemistry, Vol. 290, No. 6, 06.02.2015, p. 3500-3507.

Research output: Contribution to journalArticle

McCabe, Jacqueline M. ; Leahy, Daniel J. / Smoothened goes molecular : New pieces in the hedgehog signaling puzzle. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 6. pp. 3500-3507.
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