Smooth muscle neoplasms of the urinary bladder: A clinicopathologic study of 51 cases

Thomas K. Lee, Hiroshi Miyamoto, Adeboye O. Osunkoya, Charles C. Guo, Sharon W. Weiss, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

Smooth muscle neoplasms of the urinary bladder are relatively rare. We report the largest series to date examining the clinicopathologic features of leiomyomas and leiomyosarcomas of the bladder. This study sought to clarify several issues relating to smooth muscle neoplasms of the urinary bladder: (1) How to distinguish leiomyomas of the bladder from normal muscularis propria on transurethral resection (TUR) specimens; (2) Whether symplastic leiomyomas can be diagnosed in the bladder; (3) Can leiomyoma be definitively diagnosed on biopsy or TUR without the risk of there being unsampled leiomyosarcoma; and (4) Is the grade of leiomyosarcoma seen on biopsy or TUR heterogeneous and hence possibly not representative of the true grade. Thirty-one leiomyomas and 20 leiomyosarcoma cases of urinary bladder from 3 tertiary care medical centers were examined. Leiomyosarcoma cases were subdivided into low-grade and high-grade based on mitotic count (5/10HPF) and nuclear atypia. The mean age of the patients with leiomyoma and leiomyosarcoma was 52 and 58, respectively. The M:F ratio was significantly higher in patients with leiomyosarcoma (2:1) compared with leiomyoma (1:3), p

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume34
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

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Muscle Neoplasms
Leiomyosarcoma
Leiomyoma
Smooth Muscle
Urinary Bladder
Biopsy
Tertiary Care Centers

Keywords

  • Bladder
  • Leiomyoma
  • Leiomyosarcoma
  • Smooth muscle neoplasm

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Smooth muscle neoplasms of the urinary bladder : A clinicopathologic study of 51 cases. / Lee, Thomas K.; Miyamoto, Hiroshi; Osunkoya, Adeboye O.; Guo, Charles C.; Weiss, Sharon W.; Epstein, Jonathan Ira.

In: American Journal of Surgical Pathology, Vol. 34, No. 4, 04.2010, p. 502-509.

Research output: Contribution to journalArticle

Lee, Thomas K. ; Miyamoto, Hiroshi ; Osunkoya, Adeboye O. ; Guo, Charles C. ; Weiss, Sharon W. ; Epstein, Jonathan Ira. / Smooth muscle neoplasms of the urinary bladder : A clinicopathologic study of 51 cases. In: American Journal of Surgical Pathology. 2010 ; Vol. 34, No. 4. pp. 502-509.
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